DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and pxn

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_031752049.1	Gene:	pxn / 100216044	XenbaseID:	XB-GENE-941407	Length:	1070	Species:	Xenopus tropicalis

Alignment Length:	382	Identity:	89/382 - (23%)
Similarity:	121/382 - (31%)	Gaps:	106/382 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 HPHQQHQQHQQQHAASTTPVPINSCPTPTGHSP--LSSSSSNSNHNNNNNNNNGGSSSN---NLH 149
            ||.::|.........|:     :.|..|:...|  ::...|.||...:|....|....|   :|.
Frog   762 HPEERHLTSNSDMFPSS-----SKCLAPSNDIPSIMAKGKSVSNSPPSNTPKPGSQLDNMLGSLQ 821

  Fly   150 SACNTLTAAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAAAAAAAAATTPTSTGPAATGS 214
            |..|.|..|.||.....|...|           :.|.|..|:...........|...   ...||
Frog   822 SDLNKLGVATVAKGVCGACKKP-----------IAGQVVTAMGKTWHPEHFVCTHCQ---EEIGS 872

  Fly   215 GNANGSGNGNGNGNGNGNGNGNGNGGGAATASAAAASKLSADCSGRTEVGHIKCEKNFE-----L 274
            .|.                                   ...|       |...|||::.     .
Frog   873 RNF-----------------------------------FERD-------GQPYCEKDYHNLFSPR 895

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGM-----QLHHTCYVRNSKLYCKMDYDRLFGVKC 334
            |..|...|.|: ::...|..||.:...|..||.     ..|.    |:.|.||:.||..:|..||
Frog   896 CFYCNGPILDK-VVTALDRTWHPEHFFCAQCGAFFGPEGFHE----RDGKAYCRKDYFDMFAPKC 955

  Fly   335 SSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAA 399
            ..|.||||...:   ...|.::|..||||..|..|...| .|...|||.:|..|..|:...|.:.
Frog   956 GGCTHAILENYI---SALNTLWHPECFVCRECFTPFING-SFFEHDGQPYCEMHYHERRGSLCSG 1016

  Fly   400 AAQHCGFVGLDEEDLLRPRDGR----RGPK-RPRTILTSQQRKQF-KASF-DQSPKP 449
            ..              :|..||    .|.| .|...:.:...||. |.:| :|:.||
Frog  1017 CQ--------------KPITGRCITAMGKKFHPEHFVCAFCLKQLNKGTFKEQNDKP 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	16/56 (29%)
		LIM	333..388	CDD:295319	21/54 (39%)
		Homeobox	427..480	CDD:278475	8/25 (32%)
pxn	XP_031752049.1	Paxillin	45..234	CDD:397550
		LIM1_Paxillin_like	837..889	CDD:259830	14/107 (13%)
		LIM2_Paxillin	896..947	CDD:188791	15/55 (27%)
		LIM3_Paxillin_like	955..1007	CDD:188724	21/55 (38%)
		LIM4_Paxillin	1014..1065	CDD:188795	13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910