DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and nkx2-1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_002935383.1	Gene:	nkx2-1 / 100135015	XenbaseID:	XB-GENE-485985	Length:	346	Species:	Xenopus tropicalis

Alignment Length:	213	Identity:	53/213 - (24%)
Similarity:	81/213 - (38%)	Gaps:	62/213 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 PKRPRTILTSQ-QRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAK 487
            |:|.|.:|.|| |..:.:..|.|........||.||....|:...|::||||.|.|||   |:||
Frog   161 PRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMK---RQAK 222

  Fly   488 QNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFS 552
                                          ||..:|::..|:|.         ..|..:|.....
Frog   223 ------------------------------DKAAQQQMQQDNSS---------CQQQQSPRRVAV 248

  Fly   553 P----DDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNL---ELQSTSSSGNQ-----HSH 605
            |    |..|..:..:..::.|    .:..|....|.:::.|.|   :...|:|:|..     ||:
Frog   249 PVLVKDGKPCQAGSNTPTAAL----QSHQQQTATAITVTSNGLGPHQSHQTNSAGQSPDLVPHSN 309

  Fly   606 SHS---NPHDMLANLNNS 620
            |.|   |....|::||:|
Frog   310 SPSSLQNQVTSLSHLNSS 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	19/53 (36%)
nkx2-1	XP_002935383.1	Homeobox	165..219	CDD:365835	21/56 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910