DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and DUXB

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001338236.1	Gene:	DUXB / 100033411	HGNCID:	33345	Length:	345	Species:	Homo sapiens

Alignment Length:	258	Identity:	61/258 - (23%)
Similarity:	96/258 - (37%)	Gaps:	62/258 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 YRHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPC 450
            |:...||:.......:||     |.:|.|  |::.|    :.:|.:|..|:.:...:|:::|.|.
Human    75 YKCFSEKDQTQGHDQSQH-----LTQEYL--PKEAR----QKQTFITWTQKNRLVQAFERNPFPD 128

  Fly   451 RKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATDDKDTND 515
            ...|:.||:.|||....:|:|||.||:...|..|....|                ...|  |.|:
Human   129 IATRKKLAEQTGLQESRIQMWFQKQRSLYLKKSRMEPMN----------------LLVD--DPNE 175

  Fly   516 KEDKCVKQE-----LGGDSSGYLGGLDSTFASQPLNPNL-----PFSPDDYPANSNDSFC---SS 567
            :.|..|...     |..|||.|.....|:...:.|.|.|     |:.|..:..:...:..   .:
Human   176 RPDATVGWHPINLFLPTDSSHYFSCSHSSSGHETLPPVLPSTQAPWDPFRFHVSQGPNVMIMQPT 240

  Fly   568 DLSLDGSNFDQ-------------LDDDADSLSLNNLELQSTSSSGNQHS-------HSHSNP 610
            ....:|...||             |..|.|:.:...|:.|....:..:||       .|||.|
Human   241 QAVQEGEKSDQPLIIPNHLLTLPILTKDLDTPTPFWLQYQEEHQNHKEHSGSGVPQVKSHSQP 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319	1/1 (100%)
		Homeobox	427..480	CDD:278475	18/52 (35%)
DUXB	NP_001338236.1	homeodomain	16..72	CDD:238039
		homeodomain	103..161	CDD:238039	20/61 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314		6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910