DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdc5l and Cdc5

DIOPT Version :9

Sequence 1:	NP_957378.2	Gene:	cdc5l / 394059	ZFINID:	ZDB-GENE-040426-821	Length:	800	Species:	Danio rerio
Sequence 2:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	510/814 - (62%)
Similarity:	622/814 - (76%)	Gaps:	33/814 - (4%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65

Zfish    66 EEEEKLLHMAKLMPTQWRTIAPIIGRTAAQCLEHYEYLLDKAAQRENEDDVGDDPRKLKPGEIDP 130
            ||:|||||:||||||||||||||||||||||||.||||||:|.::|:.:|..|||||||||||||
  Fly    66 EEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDP 130

Zfish   131 NPETKPARPDPVDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAG 195
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||
  Fly   131 NPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAG 195

Zfish   196 IDIQKKRKKKRGVDYNAEIPFEKKPAQGFYDTSMEQYDPLEPDFKRLRQQHLDGELRSEKEDRDR 260
            |. ...||:.:|:||||||||||:||.||||||.|.....||||.::|||.||||||||||:|:|
  Fly   196 IG-SGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMRQQDLDGELRSEKEERER 259

Zfish   261 KKDRQKIKKKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELEEVVKLGQASEIARQTAE 325
            |:|:||:|::||:::|:|:||.   .|..:||||||||.|||||.||::|||||:|||:|::.|.
  Fly   260 KRDKQKLKQRKENEVPTAMLQN---MEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAG 321

Zfish   326 ESGITNSASSALLSEYNVTNNSMALRTPKTPAA-QDKILQEAQNLMALTNVDTPLKGGLNTPLHE 389
            ||||  ..:.|||::|::|....|  ||:|||. .|:|:|||||:||||:.:|||||||||||||
  Fly   322 ESGI--ETTDALLADYSITPQVAA--TPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLHE 382

Zfish   390 SDFSGVTPQRQVVQTPNTVLSTPFRTPSHTGEGLTPHGGLTPKA-----------SVGVTPGRTP 443
            ||||||.|:...:.|||||::||||| ...|...||.|..||.:           :.||......
  Fly   383 SDFSGVLPKAASIATPNTVIATPFRT-QREGGAATPGGFQTPSSGALVPVKGAGGATGVVNTPAY 446

Zfish   444 LRDKLNINTEEG-GVDYTDPSFSKHMQRESREHLRLGLMSLPVPKNDFEIVLPENAEKELEETEV 507
            :||||:||.||. ||..| |:..|:.|::.:..||.||.:||.|:||:|||:||..|.|..||.
  Fly   447 VRDKLSINPEESMGVTET-PAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETN- 509

Zfish   508 DESFVEDAAEIELRKQAVRDAEREKELRQRHTSVQRDLPRPSEVNETILRPHNVEPPLTDLQQAE 572
            .|..|||.|:::.|..|.::|.|::||.:|...:||.||||:|||..||||.:.:..||:.||||
  Fly   510 SEPAVEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQAE 574

Zfish   573 ELIKREMITMIHYDCLHHPFSDAKKTKGVNSSSNNAEHI-SYLEKTPYEKVSEEELKKAGDLLLQ 636
            ||||.|||||..||.:..|..        ..|.:..|.: ||.:..|||.:|::||.||..:|.:
  Fly   575 ELIKHEMITMQLYDSVKDPVP--------GQSQHKLEQLQSYFKANPYEDISQQELAKAKQMLTE 631

Zfish   637 EMEVVKHGMGHGDLSMEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIDSLEKKLEMNRGHM 701
            ||||||..|.||:|.::.|.|||:||..||||||.|.|||||||||||||::|.||:||.||.||
  Fly   632 EMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETNRRHM 696

Zfish   702 TAEAKRAAKMEKKMKILLGGYQSRAMGLLKQLSEVWDQLEQANLELHTFMELKKQEDLAIPRRQE 766
            ..||||..|:|||:|||.||||:||..|:|||.:.:.|:||.::.|.||..|.:||.:|:|||.|
  Fly   697 AKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQEAIAVPRRLE 761

Zfish   767 ALREDVQRQQEREKELQQRFADLMLDKQTLSSKI 800
            :|:|||:||.:|||||||::|.|:.::.:|.|:|
  Fly   762 SLQEDVRRQMDREKELQQKYASLVEERDSLYSQI 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc5l	NP_957378.2	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..107	CDD:212557	47/50 (94%)
		SANT	60..106	CDD:197842	42/45 (93%)
		Myb_Cef	404..653	CDD:288664	116/261 (44%)
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..108	CDD:212557	47/51 (92%)
		SANT	60..104	CDD:197842	40/43 (93%)
		Myb_Cef	397..648	CDD:288664	116/261 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580545
Domainoid	1	1.000	458	1.000	Domainoid score	I469
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13291
Inparanoid	1	1.050	963	1.000	Inparanoid score	I311
OMA	1	1.010	-	-		QHG55711
OrthoDB	1	1.010	-	-		D195986at33208
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		oto39306
orthoMCL	1	0.900	-	-		OOG6_102607
Panther	1	1.100	-	-	LDO	PTHR45885
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R188
SonicParanoid	1	1.000	-	-		X1623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940