Protein Alignment CG4328 and LHX8

DIOPT Version :10

• Sequence 1: NP_648567.2
• Gene: CG4328 / 39405
• FlyBaseID: FBgn0036274
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: XP_016856805.1
• Gene: LHX8 / 431707
• HGNCID: 28838
• Length: 363
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 95/318 - (29%)
• Similarity: 144/318 - (45%)
• Gaps: 48/318 - (15%)

  Fly   154 GMDGFATP-----------AAPPSASNTPQAPLGMASNSGMGMELGLAMASPQLSQCAHCCQPIC 207
            |.:|..:|           :||.|.|::|::   |||.||         ..|....|..|...|.
Human    21 GEEGLVSPEGAGDEDSCSSSAPLSPSSSPRS---MASGSG---------CPPGKCVCNSCGLEIV 73

  Fly   208 DRYIMRVVENSFHEGCLKCTAC--SLHLVHSCYAREGKLYCRVDYERLYIRNHCLGCGLKIAADE 270
            |:|:::|.:..:|..||.|:.|  ||....|||.::..::|::||.|.| ...|..||..|.:.:
Human    74 DKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRY-GTRCSRCGRHIHSTD 137

  Fly   271 LVMRCHENVFHLKCFACVVCGALLKKGEQYVVKQGQLFCRFDYE-------KEVEMLQGYDFYGD 328
            .|.|...||:||.||||..|...|..||::.:.:.::.||..|:       :|||...|....|.
Human   138 WVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGA 202

  Fly   329 ELFPPKLDGRRGPKRPRTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQR 393
            .|....::..:..||.||.....|.:..:|.|.....|..:..:.||:.||||.|::||||||.|
Human   203 LLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCR 267

  Fly   394 AKVKK-IQKKAKQEPPSKGASDSQDSQESL-----------DSSLATKI---KDEAHS 436
            |:.|| :........|......|:.|...|           |.::.|.:   .|:.|:
Human   268 ARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDDTHA 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	18/53 (34%)
		LIM	259..313	CDD:413332	20/53 (38%)
		COG5576	<332..439	CDD:227863	33/120 (28%)
		HOX	341..393	CDD:197696	21/51 (41%)
LHX8	XP_016856805.1	LIM1_Lhx7_Lhx8	64..119	CDD:188767	18/54 (33%)
		LIM2_Lhx7_Lhx8	126..180	CDD:188769	20/53 (38%)
		Homeodomain	216..272	CDD:459649	23/55 (42%)