DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4328 and LMX1B

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001167617.1	Gene:	LMX1B / 4010	HGNCID:	6654	Length:	406	Species:	Homo sapiens

Alignment Length:	402	Identity:	166/402 - (41%)
Similarity:	219/402 - (54%)	Gaps:	82/402 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 GMGME----------LGLAMAS--PQLSQCAHCCQPICDRYIMRVVENSFHEGCLKCTACSLHLV 234
            |:.||          ||:.:.|  |..:.|..|.:||.||::|||.|:|:||.||:|.||...|.
Human    27 GIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALT 91

  Fly   235 HSCYAREGKLYCRVDYERLYIRNHCLGCGLKIAADELVMRCHENVFHLKCFACVVCGALLKKGEQ 299
            .|||.|:.||||:.||::|:... |.||..|||..|.|||..|.|:||.||.|.||...|:||::
Human    92 TSCYFRDRKLYCKQDYQQLFAAK-CSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDE 155

  Fly   300 YVVKQGQLFCRFDYEKEVEML-----------QGYDFYGDELFPPKLDGR------------RGP 341
            :|:|:|||.|:.|||||.::|           :..|..|| :.|.|..|.            |.|
Human   156 FVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGD-MKPAKGQGSQSKGSGDDGKDPRRP 219

  Fly   342 KRPRTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQ- 405
            |||||||.||||||||||||||.||||||||.||.:||||:|:|||||||||||:||:.::.:|
Human   220 KRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQ 284

  Fly   406 ------------EP-PSKGASDSQDSQESLDSSLATKIKDEAH-SDSESQL----ESPYSTT--- 449
                        || |.:|.     .||.|.|.:...:..... :..:.|:    :|||.::
Human   285 QEQQNSQRLGQGEPGPGQGL-----GQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPF 344

  Fly   450 SDGLTRMRCTIKDEQEQVPFNCMETNKENCNKNSEPILNTILGLS-YATFQQLMGPFAQTPMINP 513
            ..|||         ..|:|.|....:..:.:.:...:.:..||.| ..:.|..:|        ||
Human   345 QQGLT---------PPQMPGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVG--------NP 392

  Fly   514 IDRLYSMQSSYF 525
            ||||||||||||
Human   393 IDRLYSMQSSYF 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	28/51 (55%)
		LIM	259..313	CDD:295319	28/53 (53%)
		COG5576	<332..439	CDD:227863	63/133 (47%)
		HOX	341..393	CDD:197696	44/51 (86%)
LMX1B	NP_001167617.1	LIM1_Lmx1b	56..108	CDD:188757	28/51 (55%)
		LIM2_Lmx1a_Lmx1b	115..169	CDD:188764	28/53 (53%)
		Homeobox	222..275	CDD:278475	45/52 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6855
eggNOG	1	0.900	-	-		E33208_3BAC6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3205
Isobase	1	0.950	-	0	Normalized mean entropy	S3240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323174at33208
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X1182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.810