Protein Alignment CG4328 and Lmx1a

DIOPT Version :10

• Sequence 1: NP_648567.2
• Gene: CG4328 / 39405
• FlyBaseID: FBgn0036274
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 212/675 - (31%)
• Similarity: 295/675 - (43%)
• Gaps: 188/675 - (27%)

  Fly     4 EHHPMQIGMFPMD---IKCQQQQLGAGQL--PQTGGL-----NQLLLLNGNERMLT------TPT 52
            |.:||...:.|:.   ...||...||..|  |..|.:     |.|.|.|.|..:.|      :||
  Fly     3 EFYPMPTNLNPVGGSLYSLQQNHGGARFLDNPNPGSMTASSGNSLHLSNSNNNLPTSISGNNSPT 67

  Fly    53 TAAT---------------------------------SVVVAAGRSASTKAGVAHNDKMASVSRT 84
            ..|:                                 |.......|..|..|   :..::|.|..
  Fly    68 ATASLTGQHQQHQQQQHQQQQQHPHQQHQQHQQQHAASTTPVPINSCPTPTG---HSPLSSSSSN 129

  Fly    85 VNGSCSNHNSSNSSSSSSTNSSSN----------------------------------------- 108
            .|.:.:|:|::..|||::.:|:.|
  Fly   130 SNHNNNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAA 194

  Fly   109 ---MAINKQPMGMGP---GTGTGMGTGTGHGPGPPNHTHCNRITLGECSLNGMDGFATPAAPPSA 167
               .|....|...||   |:|...|:|.|:|.|..|         |..:.||..|.|..|:..:|
  Fly   195 AAAAAAATTPTSTGPAATGSGNANGSGNGNGNGNGN---------GNGNGNGNGGGAATASAAAA 250

  Fly   168 SNTPQAPLGMASNSGMGMELGLAMASPQLSQCAHCCQPICDRYIMRVVENSFHEGCLKCTACSLH 232
            |.       ::::.....|:|..........|..|.|.|.||::|.|.:.::||.||.|..|.:.
  Fly   251 SK-------LSADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQ 308

  Fly   233 LVHSCYAREGKLYCRVDYERLY-IRNHCLGCGLKIAADELVMRCHEN-VFHLKCFACVVCGALLK 295
            |.|:||.|..||||::||:||: ::  |..|...|...|||||...| ||||.||.|..|...|:
  Fly   309 LHHTCYVRNSKLYCKMDYDRLFGVK--CSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQ 371

  Fly   296 KGEQYVVKQGQLFC-RFDYEKEVEM----LQGYDFYG---DELFPPKLDGRRGPKRPRTILNTQQ 352
            ||||::::.||||| |.|.|||:.:    .|...|.|   ::|..|: |||||||||||||.:||
  Fly   372 KGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPR-DGRRGPKRPRTILTSQQ 435

  Fly   353 RRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEPPSKG------ 411
            |:.|||||:.||||||||||.||||||||:|:|||||||||||:||||:||||...|.|
  Fly   436 RKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGR 500

  Fly   412 ------ASDSQDSQESLDSSLATKIKDEAHSDSESQL--------------ESPYS------TTS 450
                  |:|.:|:.:..|..    :|.|...||...|              ..|:|      .::
  Fly   501 GTGNSSATDDKDTNDKEDKC----VKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYPANSN 561

  Fly   451 DGLTRMRCT------------IKDEQEQVPFNCMETNKENCNKNSEPILNTILGLSYATFQQLMG 503
            |..    |:            :.|:.:.:..|.:|....:.:.|..       ..|::....::.
  Fly   562 DSF----CSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQH-------SHSHSNPHDMLA 615

  Fly   504 PFAQTPMINPIDRLYSMQSSYFRPE 528
            .. ...:|||||:||.||:|||..|
  Fly   616 NL-NNSLINPIDKLYLMQNSYFSSE 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	24/51 (47%)
		LIM	259..313	CDD:413332	28/55 (51%)
		COG5576	<332..439	CDD:227863	69/118 (58%)
		HOX	341..393	CDD:197696	42/51 (82%)
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	24/51 (47%)
		LIM	333..388	CDD:413332	27/56 (48%)
		Homeodomain	425..481	CDD:459649	45/55 (82%)