DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4328 and pou3f2b

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_571235.1	Gene:	pou3f2b / 30397	ZFINID:	ZDB-GENE-980526-370	Length:	378	Species:	Danio rerio

Alignment Length:	368	Identity:	68/368 - (18%)
Similarity:	113/368 - (30%)	Gaps:	147/368 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VNGSCSNHNSSNSSSS-------SSTNSSSNMAINKQPM----GMGPGTGTGMGTG--------- 129
            |:.:..||:.|.:..:       |...|:....|..||.    |:.||:|.|:...
Zfish   107 VHQTHGNHHDSRAWRTTTAAHIPSMATSNGQSLIYSQPSFSVNGLIPGSGQGIHHHSMRDAHEDH 171

  Fly   130 -----TGHGPGPPNHTHCNRITLGECSLNGMDGFATPAAPPSASNTPQAPLGMASNSGMGMELGL 189
                 :.||..|..|.|.:..:..:               .|..:||
Zfish   172 HSPHLSDHGHPPSQHQHQSHQSHHD---------------HSDEDTP------------------ 203

  Fly   190 AMASPQLSQCAHCCQPICDRYIMRVVENSFHEGCLKCTACSLHLVHSCYAREGKLY-----CRVD 249
              .|..|.|.|       .::..|.::..|.:..:.....:|:         |.::     ||.:
Zfish   204 --TSDDLEQFA-------KQFKQRRIKLGFTQADVGLALGTLY---------GNVFSQTTICRFE 250

  Fly   250 YERLYIRNHCLGCGLKIAADELVMRCHENVFHLKCFACVVCGALLKKGEQYVVKQGQLFCRFDYE 314
            ..:|..:|.|                     .||        .||.|                :.
Zfish   251 ALQLSFKNMC---------------------KLK--------PLLNK----------------WL 270

  Fly   315 KEVEMLQGYDFYGDELFPPKLD-----GRRGPKRPRTILNTQQRRAFKASFEVSPKPCRKVRENL 374
            :|.:...|        .|..||     ||:  ::.||.:....:.|.::.|...|||......:|
Zfish   271 EEADSTSG--------SPTSLDKIAAQGRK--RKKRTSIEVSVKGALESHFLKCPKPAASEITSL 325

  Fly   375 AKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEPPSKGASDSQD 417
            |....|...:|:|||.|:|      ||:.:..||......::|
Zfish   326 ADSLQLEKEVVRVWFCNRR------QKEKRMTPPGGPLPGTED 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	7/56 (13%)
		LIM	259..313	CDD:295319	6/53 (11%)
		COG5576	<332..439	CDD:227863	26/91 (29%)
		HOX	341..393	CDD:197696	15/51 (29%)
pou3f2b	NP_571235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..118		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..205		12/88 (14%)
		POU	200..274	CDD:197673	21/154 (14%)
		Homeobox	295..348	CDD:278475	18/58 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378		3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030