DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4328 and pou3f3b

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_958855.2	Gene:	pou3f3b / 30321	ZFINID:	ZDB-GENE-980526-140	Length:	443	Species:	Danio rerio

Alignment Length:	501	Identity:	93/501 - (18%)
Similarity:	158/501 - (31%)	Gaps:	183/501 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IKCQQQQLGAGQLPQTGGLNQLLLLNGNERMLTTPTTAATSVVVAAGRSASTKAGVAHNDKMASV 81
            :|..|.....|.:..:.|.:  :|.:.::.:.:.|..||.:   ||...|:.:||    ...:|.
Zfish    50 VKMVQSDFMQGAMAASNGGH--MLSHAHQWVTSLPHAAAAA---AAAAVAAAEAG----SPWSSS 105

  Fly    82 SRTVNGSCSNHNSSNSSSSSSTNSSSNMAINKQPMGMGPGTGTGMGTGTGHGPGP---PNHTHCN 143
            ...:.||....:..|:|.....:|                 ||.:     |...|   |:.||.
Zfish   106 PVGMTGSPQQQDVKNNSGRDDLHS-----------------GTAL-----HHRAPHLGPHQTHA- 147

  Fly   144 RITLGECSLNGMDGFATPAAPPSASNTPQAPLGMASNSGMGMELGLAMASPQLSQCAHCCQPICD 208
                      |..|..|.|..||.:.:.|....:..:...|..:. .|.||..||
Zfish   148 ----------GAWGSTTAAHIPSLTGSQQQQQSLIYSQPGGFTVN-GMLSPPGSQ---------- 191

  Fly   209 RYIMRVVENSFHEGCLKCTACSLHLVHSCYAREGKLYCRVDYERLYIRNHCLGCGLKIAADELVM 273
                    :..|.|.::  ..:..|.||.:          .:...:...|
Zfish   192 --------SLVHPGLVR--GDTPELDHSSH----------HHHHHHQHQH--------------- 221

  Fly   274 RCHENVFH------------------LKCFACVVCGALLKKGEQYVVK---------------QG 305
              |:...|                  |:.||        |:.:|..:|               .|
Zfish   222 --HQQAHHGVNSHDPHSDEDTPTSDDLEHFA--------KQFKQRRIKLGFTQADVGLALGTLYG 276

  Fly   306 QLF-----CRFD------------------YEKEVEMLQGYDFYGDELFPPKLD-----GRRGPK 342
            .:|     |||:                  :.:|.:...|        .|..:|     ||:  :
Zfish   277 NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTG--------SPTSIDKIAAQGRK--R 331

  Fly   343 RPRTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEP 407
            :.||.:....:.|.::.|...|||..:...:||.:..|...:|:|||.|:|      ||:.:..|
Zfish   332 KKRTSIEVSVKGALESHFLKCPKPSAQEITSLADNLQLEKEVVRVWFCNRR------QKEKRMTP 390

  Fly   408 PSKGASDSQD---SQESLDSSLATKIKDEAHSDSESQLESPYSTTS 450
            |  |...:.:   ||......|...:||.:.:......:...:|||
Zfish   391 P--GVPQTPEDVYSQVGNGHFLVDYLKDASLTGPSEPGDQRVTTTS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	5/51 (10%)
		LIM	259..313	CDD:295319	13/109 (12%)
		COG5576	<332..439	CDD:227863	30/114 (26%)
		HOX	341..393	CDD:197696	15/51 (29%)
pou3f3b	NP_958855.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..150		14/82 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..244		13/109 (12%)
		POU	238..312	CDD:197673	12/81 (15%)
		Homeobox	333..386	CDD:278475	18/58 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030