DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4328 and Pou3f4

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_032927.1	Gene:	Pou3f4 / 18994	MGIID:	101894	Length:	361	Species:	Mus musculus

Alignment Length:	388	Identity:	79/388 - (20%)
Similarity:	131/388 - (33%)	Gaps:	144/388 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TTAATSVV----VAAGRSASTKAGVAHNDKMASVSRTVNGSCSNH----NSSNSSSSSSTNSSSN 108
            :|.|||.:    |..||.......:.|: :...|:.  :...:||    .:|.:.:||.|:|...
Mouse    69 STLATSPLDQQDVKPGREDLQLGAIIHH-RSPHVAH--HSPHTNHPNAWGASPAPNSSITSSGQP 130

  Fly   109 MAINKQPMGMGPGTGTGMGTGTGHGPGPPNHTHCNRITLGECSLNGMDGFATPAAPPSASNTPQA 173
            :.:..|| |.   |.:||   ..||                    |:    ||  ||:|::|...
Mouse   131 LNVYSQP-GF---TVSGM---LEHG--------------------GL----TP--PPAAASTQSL 162

  Fly   174 PLGMASNSGMGMELGLAMASPQLSQCAHCCQ-------PICD-------RYIMRVVENSFHEGCL 224
            ...:......| |||           :|.||       |..|       ::..|.::..|.:..:
Mouse   163 HPVLREPPDHG-ELG-----------SHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADV 215

  Fly   225 KCTACSLHLVHSCYAREGKLY-----CRVDYERLYIRNHCLGCGLKIAADELVMRCHENVFHLKC 284
            .....:|:         |.::     ||.:..:|..:|.|                     .||
Mouse   216 GLALGTLY---------GNVFSQTTICRFEALQLSFKNMC---------------------KLK- 249

  Fly   285 FACVVCGALLKKGEQYVVKQGQLFCRFDYEKEVEMLQGYDFYGDELFPPKLD-----GRRGPKRP 344
                   .||.|                :.:|.:...|        .|..:|     ||:  ::.
Mouse   250 -------PLLNK----------------WLEEADSSTG--------SPTSIDKIAAQGRK--RKK 281

  Fly   345 RTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEP 407
            ||.:....:...:..|...|||..:...:||....|...:|:|||.|:|.|.|::.....|:|
Mouse   282 RTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	11/70 (16%)
		LIM	259..313	CDD:295319	6/53 (11%)
		COG5576	<332..439	CDD:227863	23/81 (28%)
		HOX	341..393	CDD:197696	14/51 (27%)
Pou3f4	NP_032927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..131		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..192		18/88 (20%)
		POU	186..260	CDD:197673	17/127 (13%)
		Homeobox	281..335	CDD:395001	16/53 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..361		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030