DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4328 and Pou3f2

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_032925.1	Gene:	Pou3f2 / 18992	MGIID:	101895	Length:	445	Species:	Mus musculus

Alignment Length:	487	Identity:	97/487 - (19%)
Similarity:	139/487 - (28%)	Gaps:	212/487 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SCSNHNSSNSSSSSSTNSS-----------------------SNMAINKQPM------------- 116
            :.|||.|..:||:|..::.                       ..:..|..|:
Mouse     4 AASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHG 68

  Fly   117 ---GMGPGTGTGMGTGTGHGPGPPNHTHCNRITLGECSLNGMDGFATPAAPPSASNTPQAPLGMA 178
               |.|.|.|.|.|.|.|.|.|.|..|.    .||:           |...||.         :.
Mouse    69 GGGGGGGGGGGGGGGGGGGGDGSPWSTS----PLGQ-----------PDIKPSV---------VV 109

  Fly   179 SNSGMGMEL----GLAMASPQLSQCAHCCQPICDRYIMRVVENSFH-----------EGCLKCTA 228
            ...|.|.||    .|.....|..|.....|....:...:..:...|           .|..:..|
Mouse   110 QQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAA 174

  Fly   229 CSLHLVHSCYAREGKLYCRVDYERLYIR-----NHCLGC----------GLKIAADELVMRCHEN 278
            .:.||..|..|..|.|        ||.:     |..||.          ||:.|.||.....|..
Mouse   175 AAAHLPPSMGASNGGL--------LYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHP 231

  Fly   279 VFH-------------------------------------LKCFACVVCGALLKKGEQYVVK--- 303
            ..|                                     |:.||        |:.:|..:|
Mouse   232 HPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFA--------KQFKQRRIKLGF 288

  Fly   304 ------------QGQLF-----CRFD------------------YEKEVEMLQGYDFYGDELFPP 333
                        .|.:|     |||:                  :.:|.:...|        .|.
Mouse   289 TQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSG--------SPT 345

  Fly   334 KLD-----GRRGPKRPRTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQR 393
            .:|     ||:  ::.||.:....:.|.::.|...|||..:...:||....|...:|:|||.|:|
Mouse   346 SIDKIAAQGRK--RKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRR 408

  Fly   394 AKVKKIQKKAKQEPPS---KGASD----SQDS 418
                  ||:.:..||.   .||.|    |:|:
Mouse   409 ------QKEKRMTPPGGTLPGAEDVYGGSRDT 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	10/62 (16%)
		LIM	259..313	CDD:295319	20/138 (14%)
		COG5576	<332..439	CDD:227863	29/99 (29%)
		HOX	341..393	CDD:197696	15/51 (29%)
Pou3f2	NP_032925.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..173		27/132 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..269		9/65 (14%)
		POU	264..338	CDD:197673	12/81 (15%)
		Homeobox	359..413	CDD:395001	18/59 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..445		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030