DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4328 and Pou3f1

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_035271.1	Gene:	Pou3f1 / 18991	MGIID:	101896	Length:	449	Species:	Mus musculus

Alignment Length:	393	Identity:	77/393 - (19%)
Similarity:	118/393 - (30%)	Gaps:	139/393 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GRSASTKAGVAHNDKMASVSRTVNGSCSNHNSSNSSSSSSTNSSSNMAINKQPMGM--------G 119
            |......|.:.|.....:.:....|..::|.....|.|.......    ..||:|:        |
Mouse   105 GGGGGFHARLVHQGAAHAGAAWAQGGTAHHLGPAMSPSPGAGGGH----QPQPLGLYAQAAYPGG 165

  Fly   120 PGTG-TGM----GTGTGHG---------------PGPPNHTHCNRITLGECSLNGMDGFATPAAP 164
            .|.| .||    |.|.|.|               |.||.|...:....|.....|:...|....|
Mouse   166 GGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHP 230

  Fly   165 PSASNTPQAPLGMASNSGMGMELGL-----AMASPQLSQCAHCCQPICDRYIMRVVENSFHEGCL 224
            .:              .|.|..:|.     |.:|..|.|.|       .::..|.::..|.:..:
Mouse   231 GA--------------GGGGSSVGEHSDEDAPSSDDLEQFA-------KQFKQRRIKLGFTQADV 274

  Fly   225 KCTACSLHLVHSCYAREGKLY-----CRVDYERLYIRNHCLGCGLKIAADELVMRCHENVFHLKC 284
            .....:|:         |.::     ||.:..:|..:|.|                     .||
Mouse   275 GLALGTLY---------GNVFSQTTICRFEALQLSFKNMC---------------------KLK- 308

  Fly   285 FACVVCGALLKKGEQYVVKQGQLFCRFDYEKEVEMLQGYDFYGDELFPPKLD-----GRRGPKRP 344
                   .||.|                :.:|.:...|        .|..||     ||:  ::.
Mouse   309 -------PLLNK----------------WLEETDSSSG--------SPTNLDKIAAQGRK--RKK 340

  Fly   345 RTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEPPS 409
            ||.:....:.|.::.|...|||.......||....|...:|:|||.|:|.|.|::       .|:
Mouse   341 RTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRM-------TPA 398

  Fly   410 KGA 412
            .||
Mouse   399 AGA 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	7/56 (13%)
		LIM	259..313	CDD:295319	6/53 (11%)
		COG5576	<332..439	CDD:227863	26/86 (30%)
		HOX	341..393	CDD:197696	15/51 (29%)
Pou3f1	NP_035271.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..108		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..152		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..251		13/80 (16%)
		POU	245..319	CDD:197673	20/134 (15%)
		Homeobox	340..393	CDD:278475	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..449		4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030