Protein Alignment CG4328 and Lhx2

DIOPT Version :10

• Sequence 1: NP_648567.2
• Gene: CG4328 / 39405
• FlyBaseID: FBgn0036274
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001407283.1
• Gene: Lhx2 / 16870
• MGIID: 96785
• Length: 414
• Species: Mus musculus
• Alignment Length: 376
• Identity: 98/376 - (26%)
• Similarity: 156/376 - (41%)
• Gaps: 97/376 - (25%)

  Fly   190 AMASPQLSQCAHCCQPICDRYIMRVVENSFHEGCLKCTACSLHLVH--SCYAREGKLYCRVDY-- 250
            :::|.:.:.||.|...|.|||.:..|:..:|..||||..|.|:|..  :|::::|.:||:.||
Mouse    44 SISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYS 108

  Fly   251 ------ERLYIRNHCLGCGLKIAADELVMRCHENVFHLKCFACVVCGALLKKGEQYVVKQGQLFC 309
                  .|.:....|..|.|.|:|.|:|||..:.|:||.||.|..|..:|..|:.:.:|...::|
Mouse   109 PSLHGPHRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYC 173

  Fly   310 RFDYEKEVEMLQG-YDFY-------------------------GDELFPPKLDG----------- 337
            |..:|   .:||| |..:                         .:.|..|..:|
Mouse   174 RLHFE---ALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVGTVQKGRPRK 235

  Fly   338 RRGP-----------------------------------KRPRTILNTQQRRAFKASFEVSPKPC 367
            |:.|                                   ||.||.....|.|..|:.|.::..|.
Mouse   236 RKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPD 300

  Fly   368 RKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEPPSKGASDSQDS--QESLDSSLATKI 430
            .|..:.||:.|||:.|::||||||.|||.::  ...:||  :.|...:.|:  |....|..|:::
Mouse   301 AKDLKQLAQKTGLTKRVLQVWFQNARAKFRR--NLLRQE--NTGVDKTSDATLQTGTPSGPASEL 361

  Fly   431 KDEAHSDSE-----SQLESP-YSTTSDGLTRMRCTIKDEQEQVPFNCMETN 475
            .:.:.|.|.     :.|.|| ..|.:..||.:...::..:...|.....||
Mouse   362 SNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTN 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	22/61 (36%)
		LIM	259..313	CDD:413332	21/53 (40%)
		COG5576	<332..439	CDD:227863	37/154 (24%)
		HOX	341..393	CDD:197696	23/86 (27%)
Lhx2	NP_001407283.1	LIM1_Lhx2	43..106	CDD:188853	21/61 (34%)
		LIM2_Lhx2_Lhx9	119..177	CDD:188763	21/57 (37%)
		COG5576	<255..386	CDD:227863	37/134 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..278		2/19 (11%)
		Homeodomain	275..331	CDD:459649	25/55 (45%)
		Nuclear localization signal. /evidence=ECO:0000255	315..331		10/15 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..383		12/48 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..414		3/18 (17%)