DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4328 and Lmx1b

DIOPT Version :9

Sequence 1:	NP_648567.2	Gene:	CG4328 / 39405	FlyBaseID:	FBgn0036274	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_446161.1	Gene:	Lmx1b / 114501	RGDID:	620843	Length:	402	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	163/408 - (39%)
Similarity:	218/408 - (53%)	Gaps:	98/408 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 GMGME----------LGLAMAS--PQLSQCAHCCQPICDRYIMRVVENSFHEGCLKCTACSLHLV 234
            |:.||          ||:.:.|  |..:.|..|.:||.||::|||.|:|:||.||:|.||...|.
  Rat    27 GIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALT 91

  Fly   235 HSCYAREGKLYCRVDYERLYIRNHCLGCGLKIAADELVMRCHENVFHLKCFACVVCGALLKKGEQ 299
            .|||.|:.||||:.||::|:... |.||..|||..|.|||..|.|:||.||.|.||...|:||::
  Rat    92 TSCYFRDRKLYCKQDYQQLFAAK-CSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDE 155

  Fly   300 YVVKQGQLFCRFDYEKEVEML-----------QGYDFYGDELFPPKLDGR------------RGP 341
            :|:|:|||.|:.|||||.::|           :..|..|| :.|.|..|.            |.|
  Rat   156 FVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGD-MKPAKGQGSQNKGSGDDGKDPRRP 219

  Fly   342 KRPRTILNTQQRRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQE 406
            |||||||.||||||||||||||.||||||||.||.:||||:|:|||||||||||:||:.::.:|:
  Rat   220 KRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQ 284

  Fly   407 PPSKGASDSQDSQESLDSSLATKIKDEAHS-----DSESQL----ESPYSTT---SDGLTRMRCT 459
                  .:.|:||......|:::::....|     ..:.|:    :|||.::   ..|||
  Rat   285 ------QEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLT----- 338

  Fly   460 IKDEQEQVPFNCME-----------------TNKENCNKNSEPILNTILGLSYATFQQLMGPFAQ 507
                ..|:|.:.|.                 |:..:|...|..:         .:.|..:|
  Rat   339 ----PPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDV---------GSLQARVG---- 386

  Fly   508 TPMINPIDRLYSMQSSYF 525
                ||||||||||||||
  Rat   387 ----NPIDRLYSMQSSYF 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	28/51 (55%)
		LIM	259..313	CDD:295319	28/53 (53%)
		COG5576	<332..439	CDD:227863	60/123 (49%)
		HOX	341..393	CDD:197696	44/51 (86%)
Lmx1b	NP_446161.1	LIM1_Lmx1b	56..108	CDD:188757	28/51 (55%)
		LIM2_Lmx1a_Lmx1b	115..169	CDD:188764	28/53 (53%)
		Homeobox	222..276	CDD:395001	45/53 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6686
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3154
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323174at33208
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970