DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and INP51

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_012264.3	Gene:	INP51 / 854815	SGDID:	S000001264	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	341	Identity:	102/341 - (29%)
Similarity:	157/341 - (46%)	Gaps:	62/341 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 QKEITVFVGTWNMNGHSPPKQLNDFVLPANV---EHVPDIVVMGTQ---ESTPD---------RF 437
            :|:|::|.||:|::|..|...:.|::.|.::   :.:.|:.|:|.:   |.||.         |.
Yeast   524 EKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQ 588

  Fly   438 EWEVTIQETL-GP----SHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRT--GSAFRTK 495
            .||..|...| ||    .::...:|.||.:.|.::|..  ..|..|........:|  |.....|
Yeast   589 FWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNE--TEYSKVKHIEGDVKKTGFGGMASNK 651

  Fly   496 GAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNV 560
            ||||:||....|....:.|||.|..:.|::|.:|.|.|..::...:.|..:.|         |.:
Yeast   652 GAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDH---------DAI 707

  Fly   561 FWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPT 625
            .|.||.|:|:....|.:...|.:.::.       .....|||...:..|.:|..|.|..|.||||
Yeast   708 IWMGDFNYRILMSNEDVRRKIVSKEYA-------SLFEKDQLNQQMIAGESFPYFHEMAIDFPPT 765

  Fly   626 YKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSI 690
            ||:|||::|:|||.|.|.||:|||||     .:|.|:.:                 |.|.....|
Yeast   766 YKFDPGTKNYDTSEKMRIPAWTDRIL-----SRGEVLEQ-----------------LEYKCCEDI 808

  Fly   691 TTSDHKPVWALFRTLI 706
            ..|||:||:|:||..:
Yeast   809 LFSDHRPVYAIFRARV 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	100/336 (30%)
INP51	NP_012264.3	COG5329	1..501	CDD:227637
INP51	NP_012264.3	COG5411	498..946	CDD:227698	102/341 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810