Protein Alignment INPP5E and INP53

DIOPT Version :9

• Sequence 1: NP_001261753.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_014752.3
• Gene: INP53 / 854276
• SGDID: S000005635
• Length: 1107
• Species: Saccharomyces cerevisiae
• Alignment Length: 389
• Identity: 116/389 - (29%)
• Similarity: 176/389 - (45%)
• Gaps: 83/389 - (21%)

  Fly   373 STSLLGPSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE------ 431
            ||.|...|:  :......|.:.:|::|:||.:....|:.::.|...:..|||||:|.||
Yeast   550 STKLQSMSD--KFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSA 612

  Fly   432 -------STPDRFEWEVTIQETLG---PSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSV 486
                   .:...| ||..:.:.|.   ..::|.....:.:|.:..:::.|...|....|.|:.
Yeast   613 GSILNADYSKSSF-WENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATK-- 674

  Fly   487 RTGSAFR----TKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQR 547
            :||  ||    .||||:|.|....||..||.|||.|....|:||.||.:.|:..:...|......
Yeast   675 KTG--FRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPH 737

  Fly   548 HKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGY----MHTDQLTSVLAD 608
            |         |::||.||:|:|:..|.|.:...:.|.:        .||    :|.||||..:..
Yeast   738 H---------DSIFWLGDMNYRINLPNEDVRRELLNQE--------EGYIDKLLHFDQLTLGINS 785

  Fly   609 GAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVST 673
            |:.|.||.|..:.|.||||||||:..:|:|.|:|.|::||||:||          .:.|:|
Yeast   786 GSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTDRIIYK----------GENLLP---- 836

  Fly   674 PTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLNNQY 737
                    |.|...| |..|||:||:|.:|..|....|...|:            :::||..:|
Yeast   837 --------LSYSDAP-IMISDHRPVYAAYRAKITFVDDKERLS------------LKKRLFTEY 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	105/339 (31%)
INP53	NP_014752.3	COG5329	1..603	CDD:227637	16/54 (30%)
		INPP5c_ScInp51p-like	566..858	CDD:197324	105/336 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810