Protein Alignment INPP5E and Synj2

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_001106842.1
• Gene: Synj2 / 84018
• RGDID: 69436
• Length: 1496
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 189/753 - (25%)
• Similarity: 274/753 - (36%)
• Gaps: 241/753 - (32%)

  Fly    73 DTSANHVNNNGSTLKSQTLPLEKSHSGL------ISFHRRAKPSSSKGKNHSHRHSTDAGSQ--- 128
            |..::.|...||      :||.....||      :..||..:.::...:.|........|.|
  Rat   243 DGVSSFVQIRGS------VPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVV 301

  Fly   129 ----SDGGADVVMR--RK---SPKHR--SPNHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSN 182
                |.||.:|:.|  :|   :..|.  :|..|...|||:...|.||.
  Rat   302 NLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKL----------------- 349

  Fly   183 SVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSS---ECASAPESPVASKTFFA----HCSPA 240
            ..|.|..|.|.|    ::.|.....|..|.|.:..:   .|....:.....:.|.|    |
  Rat   350 ENLLRPQLKLHW----DDFGVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLH---- 406

  Fly   241 AASASVARSESL-QNRSPIRPMAVSACRSRLRL------KLYPPGQELPPLQAATEPGDIKRATT 298
                  .:.||| .|..||....|.:.::...|      |::...:   .|:...:.|.:|
  Rat   407 ------LQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSR---ALEGKAKVGKLK---- 458

  Fly   299 PQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARE 363
                                  .|.|.||.   |:|     ||........|..| |:..|...|
  Rat   459 ----------------------DGARSMSR---TIQ-----SNFFDGVKQEAIKL-LLVGDVYNE 492

  Fly   364 RSYLDGR--LGSTSLLG-----PSELSRVL-----PQ---------------KEITVFVGTWNMN 401
            .|...||  |.:|:|||     .:.||.:|     |:               |.|.:.:||||:|
  Rat   493 ESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVN 557

  Fly   402 GHSP-------PKQLNDFVLPANVEHVP---------------DIVVMGTQE------------S 432
            |...       ..:|.|::|.|     |               ||..:|.:|            |
  Rat   558 GGKQFRSNLLGTTELTDWLLDA-----PQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIVNAS 617

  Fly   433 TPDRFEWEVTIQETLGPSH--VLFHATTLGTLHLAVYMR-------RDLIWYCSVPEDASMSVRT 488
            |.:|..|...:|:.:..||  :|..:..|..:.|.:::|       ||:         |..:|:|
  Rat   618 TTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDV---------AIDTVKT 673

  Fly   489 GSAFR--TKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLP--RNLPNQRHK 549
            |...:  .||||.|.|....||..|:.|||||.|.:||||..|.:.|.:.|..|  ||:
  Rat   674 GMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNI------ 732

  Fly   550 NKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRG 614
                 .:.|.||||||.|:|:....|::..:::...:       ...|..|||....:.|..|:.
  Rat   733 -----FSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDW-------KKLMEFDQLQLQKSSGKIFKD 785

  Fly   615 FMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQ----------------MQGLVIR 663
            |.|..|.|.||||||.||..:|||.|.|.||:|||:|:..::                :.|....
  Rat   786 FHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANI 850

  Fly   664 RQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWAL 701
            |.|..||.          |.|.....:..|||:||.|:
  Rat   851 RHTWSPGT----------LKYYGRAELQASDHRPVLAI 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	112/393 (28%)
Synj2	NP_001106842.1	COG5329	28..485	CDD:227637	63/316 (20%)
		EEP	547..878	CDD:469791	109/372 (29%)
		DUF1866	889..1025	CDD:286093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1047..1083
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1100..1149
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1205..1357
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1393..1413
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1442..1461
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1468..1496