DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and Synj2

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001106842.1	Gene:	Synj2 / 84018	RGDID:	69436	Length:	1496	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	189/754 - (25%)
Similarity:	274/754 - (36%)	Gaps:	243/754 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DTSANHVNNNGSTLKSQTLPLEKSHSGL------ISFHRRAKPSSSKGKNHSHRHSTDAGSQ--- 128
            |..::.|...||      :||.....||      :..||..:.::...:.|........|.|
  Rat   243 DGVSSFVQIRGS------VPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVV 301

  Fly   129 ----SDGGADVVMR--RK---SPKHR--SPNHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSN 182
                |.||.:|:.|  :|   :..|.  :|..|...|||:...|.||.
  Rat   302 NLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKL----------------- 349

  Fly   183 SVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSS---ECASAPESPVASKTFFA----HCSPA 240
            ..|.|..|.|.|    ::.|.....|..|.|.:..:   .|....:.....:.|.|    |
  Rat   350 ENLLRPQLKLHW----DDFGVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLH---- 406

  Fly   241 AASASVARSESL-QNRSPIRPMAVSACRSRLRL------KLYPPGQELPPLQAATEPGDIKRATT 298
                  .:.||| .|..||....|.:.::...|      |::...:   .|:...:.|.:|
  Rat   407 ------LQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSR---ALEGKAKVGKLK---- 458

  Fly   299 PQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARE 363
                                  .|.|.||.   |:|     ||........|..| |:..|...|
  Rat   459 ----------------------DGARSMSR---TIQ-----SNFFDGVKQEAIKL-LLVGDVYNE 492

  Fly   364 RSYLDGR--LGSTSLLG-----PSELSRVL-----PQ---------------KEITVFVGTWNMN 401
            .|...||  |.:|:|||     .:.||.:|     |:               |.|.:.:||||:|
  Rat   493 ESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVN 557

  Fly   402 GHSP-------PKQLNDFVL----------------PANVEHVPDIVVMGTQE------------ 431
            |...       ..:|.|::|                ||      ||..:|.:|
  Rat   558 GGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPA------DIFAVGFEEMVELSAGNIVNA 616

  Fly   432 STPDRFEWEVTIQETLGPSH--VLFHATTLGTLHLAVYMR-------RDLIWYCSVPEDASMSVR 487
            ||.:|..|...:|:.:..||  :|..:..|..:.|.:::|       ||:         |..:|:
  Rat   617 STTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDV---------AIDTVK 672

  Fly   488 TGSAFR--TKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLP--RNLPNQRH 548
            ||...:  .||||.|.|....||..|:.|||||.|.:||||..|.:.|.:.|..|  ||:
  Rat   673 TGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNI----- 732

  Fly   549 KNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFR 613
                  .:.|.||||||.|:|:....|::..:::...:       ...|..|||....:.|..|:
  Rat   733 ------FSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDW-------KKLMEFDQLQLQKSSGKIFK 784

  Fly   614 GFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQ----------------MQGLVI 662
            .|.|..|.|.||||||.||..:|||.|.|.||:|||:|:..::                :.|...
  Rat   785 DFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDAN 849

  Fly   663 RRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWAL 701
            .|.|..||.          |.|.....:..|||:||.|:
  Rat   850 IRHTWSPGT----------LKYYGRAELQASDHRPVLAI 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	112/394 (28%)
Synj2	NP_001106842.1	Syja_N	61..342	CDD:280532	25/104 (24%)
		EEP	547..878	CDD:294334	109/373 (29%)
		DUF1866	889..1025	CDD:286093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1393..1413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1442..1461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1468..1496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810