Protein Alignment INPP5E and Inppl1

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_075233.1
• Gene: Inppl1 / 65038
• RGDID: 68396
• Length: 1257
• Species: Rattus norvegicus
• Alignment Length: 783
• Identity: 172/783 - (21%)
• Similarity: 287/783 - (36%)
• Gaps: 241/783 - (30%)

  Fly    19 PRSGHKTASSLFGLLSKRPSKVEPHPVTPESPRLQQRPVSACGQYDVSFAKCNADTSANHVNNNG 83
            ||||..:.|...|     ||...|.|.||.:|..:..|              |..::.:|....|
  Rat   143 PRSGSTSISVPAG-----PSSPLPAPETPTTPAAESTP--------------NGLSTVSHEYLKG 188

  Fly    84 STLKSQTLPLEKSHSGLISF-HRRAKPSSSKGKNHSHRHSTDAGSQSDGGADVVMRRKSPKHRSP 147
                |..|.||....|..:. |......:|..:.||......:|.:       ::.:...:..||
  Rat   189 ----SYGLDLEAVRGGASNLPHLTRTLVTSCRRLHSEVDKVLSGLE-------ILSKVFDQQSSP 242

  Fly   148 NHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSH 212
            ...|...|.||....|::  ...:.::.:.:.|..|.:::..|.   ::.|.:|
  Rat   243 MVTRLLQQQSLPQTGEQE--LESLVLKLSVLKDFLSGIQKKALK---ALQDMSS----------- 291

  Fly   213 RPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPP 277
                     :||              ||....|:.:::::    |::...|     :|.:.|
  Rat   292 ---------TAP--------------PAPLQPSIRKAKTI----PVQAFEV-----KLDVTL--- 321

  Fly   278 GQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDG----------------------------- 313
                         ||:.:....|..:   ::...:|
  Rat   322 -------------GDLTKIGKSQKFT---LSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIK 370

  Fly   314 IEHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLLG 378
            .:.::.:.||.|...::.| ||:......||:.......|.|:...::::..
  Rat   371 SQRVQNKLGVVFEKEKDRT-QRKDFIFVSARKREAFCQLLQLMKNKHSKQDE------------- 421

  Fly   379 PSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFV-----------LPANVEHVPDIVVMGTQES 432
                    |.. |:||:|||||....|||.:..:.           :...:.|  ||.|.||||:
  Rat   422 --------PDM-ISVFIGTWNMGSVPPPKNVTSWFTSKGLGKALDEVTVTIPH--DIYVFGTQEN 475

  Fly   433 TPDRFEW----EVTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPED-------ASMSV 486
            :....||    ...::|.....:......:|..:.:||.::         ||.       ::.||
  Rat   476 SVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVK---------PEHENRISHVSTSSV 531

  Fly   487 RTGSA--FRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPR--NLPNQR 547
            :||.|  ...||||.:||...|||..||..|||:..:|.      .:|..|.||:.|  :|.:::
  Rat   532 KTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKT------TRRNQNYLDILRLLSLGDRQ 590

  Fly   548 HKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKF-PLPSHLPHGYMHTDQLTSVLADGAA 611
            ....|::..|.::||.||||:||....:::|.:|...:| ||        :..|||.........
  Rat   591 LSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPL--------LRVDQLNLEREKHKV 647

  Fly   612 FRGFMEANITFPPTYKYDPGSQNFDTSSKQR-------APAYTDRILYKYRQMQGLVIRRQTLVP 669
            |..|.|..|:|||||:|:.||::.....||:       .|::.||||:|
  Rat   648 FLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWK---------------- 696

  Fly   670 GVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLN 734
              |.| :.|:.|..|.....|.||||.||:..|.             .|:.|:.|..:|:.:..:
  Rat   697 --SYP-ETHIICNSYGCTDDIVTSDHSPVFGTFE-------------VGVTSQFISKKGLSKTSD 745

  Fly   735 NQY 737
            ..|
  Rat   746 QAY 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	104/349 (30%)
Inppl1	NP_075233.1	SH2_SHIP	17..119	CDD:198206
		PHA03247	<103..175	CDD:223021	13/36 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..181		15/56 (27%)
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	104/359 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	897..986
		SH3-binding	945..950
		NPXY motif	984..987
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1004..1115
		SAM_Ship2	1193..1255	CDD:188890