DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and Inpp5e

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_149125.1	Gene:	Inpp5e / 64436	MGIID:	1927753	Length:	647	Species:	Mus musculus

Alignment Length:	769	Identity:	246/769 - (31%)
Similarity:	352/769 - (45%)	Gaps:	153/769 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQHSSAGSEERITSSTSSPRSGHKTASSLFGLLSKRPSK-VEPHPVTPESPRLQQRPVSACGQYD 64
            ::|:.|..:.........|.:..|......|.|....|: .|.:|:.|.|     .|.....|
Mouse     8 LRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFS-----IPAKTSNQ-- 65

  Fly    65 VSFAKCNADTSANHVNNNGSTLK--SQTLPLEKSHSGLISFHRRAKPSSSKGKNHSHRHSTDAGS 127
                  |..|.||.:........  .:||.|:..     .:.||....|.:.....:..|...||
Mouse    66 ------NPQTKANLITPQPPIRPKLERTLSLDDK-----GWRRRRFRGSQEDLTVQNGASPCRGS 119

  Fly   128 QSDGGADVVMRRKSPKHRSPNHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSNSVLRRDNLSL 192
            ..|..|           :||.::|              |: |.::.....||.|......:..|.
Mouse   120 LQDSVA-----------QSPAYSR--------------PL-PCLSTSLQEIPKSRRATGSEGGSP 158

  Fly   193 S-WSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRS 256
            | ||  |..||.:.:|....||...|    ..|.|.:||  ..|..:|.|...|:| |.||:..:
Mouse   159 SLWS--DCLSGMISTSLDLLHRDAAS----GGPPSRLAS--LHASHTPPAMDLSIA-SSSLRTAN 214

  Fly   257 PIRPMAVSACRSRLRLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGIEHIEEQP 321
            .:.|.... .:.|::.:|......|.|          .|..:|       :|    |.:|
Mouse   215 KVDPEHTD-YKLRMQTRLVRAHSNLGP----------SRPRSP-------LA----GDDH----- 252

  Fly   322 GVRFMSHENMTLQRQGSGSNLARQTLMAAHALNL---IPADNARERSYLDGR-LGSTSLLGPSEL 382
                                    ::.:|.:.:|   |...:.|.||||:|. |.|.:|||..||
Mouse   253 ------------------------SIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEEL 293

  Fly   383 SRVLPQKEITVFVGTWNMNGHSP-PKQLNDFVLPANVEHVPDIVVMGTQESTPDRFEWEVTIQET 446
            :|..|.:.:.:||.||||.|... |..|::|:||...::..|:.|:|.||...||.|||..:|||
Mouse   294 ARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQET 358

  Fly   447 LGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAISFCLFGTSMLF 511
            |||.:||..:...|.|::::::||||||:||..|.::::.|..|..:||||:.:||..||||.||
Mouse   359 LGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLF 423

  Fly   512 VTSHLTAHQQKVKERVSDVKRIINALDLPRNLPN---QRHKNKDVTQNFDNVFWCGDLNFRLGEP 573
            :|||.|:...||.||:.|..|.|.||.||||:|:   .|....|||..||.|||.||.||||...
Mouse   424 ITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGG 488

  Fly   574 R---EKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNF 635
            |   |..|:  |..:..:.:.|.|     ||||..:..|:.||||.||.|.|.|:||:|.|...:
Mouse   489 RVAVEAFLK--QKPEVDVLALLQH-----DQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTY 546

  Fly   636 DTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWA 700
            |::||||.|:||||:|||.|       .:..:.|            :.|.|.|.|.||||:||:.
Mouse   547 DSTSKQRTPSYTDRVLYKSR-------HKGDICP------------MKYSSCPGIKTSDHRPVYG 592

  Fly   701 LFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLNNQY--------SGASAVCVL 746
            ||:..:|.|.|.||||||.|.|::||.|::||::.:.        ..:||||.:
Mouse   593 LFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTV 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	139/322 (43%)
Inpp5e	NP_149125.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80		17/84 (20%)
		PHA03246	<14..166	CDD:223020	39/197 (20%)
		3 X 4 AA repeats of P-X-X-P	52..243		56/254 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..131		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..196		8/24 (33%)
		INPP5c_INPP5E-like	298..596	CDD:197329	140/323 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837942
Domainoid	1	1.000	239	1.000	Domainoid score	I2277
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2558
Isobase	1	0.950	-	0	Normalized mean entropy	S4227
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000945
OrthoInspector	1	1.000	-	-		oto92572
orthoMCL	1	0.900	-	-		OOG6_104600
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.600