Protein Alignment INPP5E and inpp5e

DIOPT Version :9

• Sequence 1: NP_001261753.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_001096089.2
• Gene: inpp5e / 606579
• ZFINID: ZDB-GENE-050809-23
• Length: 635
• Species: Danio rerio
• Alignment Length: 718
• Identity: 234/718 - (32%)
• Similarity: 324/718 - (45%)
• Gaps: 182/718 - (25%)

  Fly    85 TLKSQTLPLEKSHSGLI-----------------SFHRRAKPSSSK-------GKN--------- 116
            |:.|..|..||||:..:                 |.::...||..|       |||
Zfish    28 TVLSVDLRTEKSHNEELRDIKKPYDGPKVLQDEHSLYQPRPPSLPKPMGLGMGGKNLSFDEKVRG 92

  Fly   117 ----HSHRHSTD---AGSQSDGGADVVMRRKSPKHRSPNHNRFSHQFSLCCKAEKKPM------T 168
                :|....||   .||.:|...||.         |.|....         |.::|:      .
Zfish    93 RRLRNSQESLTDPGETGSSTDSLKDVA---------SANGQTL---------ASRRPLDLQHMEM 139

  Fly   169 PPVTVRYNSIPDSNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTF 233
            ||..:|                          :|||..::.|.|
Zfish   140 PPFRIR--------------------------TGSLSETDVSPH--------------------- 157

  Fly   234 FAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPPGQELPPLQAATEPGDIKRATT 298
             ..|.|              |:..::|       ||:.|....|....|.|:.:|....::  ||
Zfish   158 -DLCDP--------------NKERMKP-------SRIVLSPLQPTGTYPLLENSTASASLR--TT 198

  Fly   299 PQHMSSPNIATQPDGIEH-IEEQPGVRFMSHENMT----LQRQGSGSNLARQTLMAAHALNLIPA 358
            .:        ...|.::: :..:.|.....|.|::    |....|.:............||.|..
Zfish   199 NR--------IDRDCLDYGVVGRRGRSERLHRNLSDSRLLDTMVSDNTSVHSMKSTYSVLNPIRP 255

  Fly   359 DNARERSYLDGR-LGSTSLLGPSELSRVLPQKEITVFVGTWNMNGHSP-PKQLNDFVLPANVEHV 421
            .:.|.||:|:|. ||:.:|||..||.|..|::.:.:::.||||.|... |..|:|.:||.:.:..
Zfish   256 RDVRNRSFLEGSVLGNGALLGAEELDRYFPERRLGIYIATWNMQGEKGLPYNLDDLLLPTDTDFA 320

  Fly   422 PDIVVMGTQESTPDRFEWEVTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSV 486
            .|:.|:|.||..|||.|||:.:||||||.:|:.:|...|.|:|.|::||||||:||..|.|:::.
Zfish   321 QDVYVIGVQEGCPDRREWEIRLQETLGPYYVMLYAAAHGVLYLTVFVRRDLIWFCSEVEHATVTT 385

  Fly   487 RTGSAFRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPN---QRH 548
            |..|..:|||||.|.|..||||.||||||.|:...||.||:.|..:||.||.||||||:   .|.
Zfish   386 RIISQIKTKGAVGIGFTFFGTSFLFVTSHFTSGDSKVYERILDYNKIIEALALPRNLPDTNPYRS 450

  Fly   549 KNKDVTQNFDNVFWCGDLNFRLGEPR---EKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGA 610
            ...|||..||.|||.||.||||.:.|   |.:|.  |.....:...|.|     ||||..:.:|:
Zfish   451 TTSDVTTRFDEVFWFGDFNFRLNKARGDVEAILN--QGVGVDMSPLLQH-----DQLTREMKEGS 508

  Fly   611 AFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPT 675
            .|:||.||:|.||||||:|.|...:||::|||.|:|||||||:.||..
Zfish   509 IFKGFQEASIHFPPTYKFDIGCDVYDTTTKQRTPSYTDRILYRNRQAD----------------- 556

  Fly   676 QPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLNNQYSGA 740
              .::.:.|.|..||.||||:||..:|:..:|.|.|.|||.||||.|.:||||:|||:..:....
Zfish   557 --DIRVIKYTSCSSIKTSDHRPVIGMFQVKLRPGRDNIPLGAGLFDRSLYLEGIRRRITRELKKR 619

  Fly   741 SAV 743
            .||
Zfish   620 EAV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	144/322 (45%)
inpp5e	NP_001096089.2	INPP5c_INPP5E-like	285..583	CDD:197329	145/323 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581739
Domainoid	1	1.000	256	1.000	Domainoid score	I2001
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2415
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000945
OrthoInspector	1	1.000	-	-		oto38660
orthoMCL	1	0.900	-	-		OOG6_104600
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.790