Protein Alignment INPP5E and inpp5b

DIOPT Version :9

• Sequence 1: NP_001261753.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: XP_009290335.3
• Gene: inpp5b / 563543
• ZFINID: ZDB-GENE-110411-228
• Length: 907
• Species: Danio rerio
• Alignment Length: 459
• Identity: 118/459 - (25%)
• Similarity: 187/459 - (40%)
• Gaps: 107/459 - (23%)

  Fly   317 IEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHAL--NLIPAD---NARERSYLDGRLGSTSL 376
            ::.|..|:....:::....|...||.|:...|....|  |||..:   |....:|::
Zfish   194 LQSQEKVKGEVKDDLIRNSQPVLSNKAQMLGMPQFGLRDNLIKCELLKNEDAYTYIE-------- 250

  Fly   377 LGPSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE---------- 431
                         ..:.|:||:|:||.:|.:.|:.::  |:....||..::|.||
Zfish   251 -------------NYSFFLGTYNVNGQTPKESLSPWL--ASTASPPDFYLIGFQELDLSKEAFLF 300

  Fly   432 -STPDRFEWEVTIQETLGP--SHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFR 493
             .||...||.:.:.:.|.|  .:.|.....|..:.|..|::.:...:.|..|..::.........
Zfish   301 NDTPKEPEWMLAVYKGLHPDAKYALVKLVRLVGIMLLFYVKAEHAPHISEVEAETVGTGVMGRMG 365

  Fly   494 TKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPN------QRHKNKD 552
            .||||:|.|....:.:..|.|||.||.::.:.|..|.|.|...:...:..|.      .:|
Zfish   366 NKGAVSIRFQFHNSDICVVNSHLAAHTEEFERRNQDFKDICRRIQFRQEDPTLPPLTILKH---- 426

  Fly   553 VTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHT-DQLTSVLADGAAFRGFM 616
                 :.|.|.||||:|:.:     || :.:.| .|.|......:|| |||...:.:...|.||.
Zfish   427 -----NIVLWLGDLNYRISD-----LE-VDHVK-DLISKKDFETLHTYDQLKRQMDEEVVFVGFT 479

  Fly   617 EANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQC 681
            |..|.|.||||||.||..:|||.|.|.||:.||||::.:.::                 |.|
Zfish   480 EGEIDFQPTYKYDTGSDQWDTSEKCRVPAWCDRILWRGKSIK-----------------QLH--- 524

  Fly   682 LLYDSVPSITTSDHKPVWALF--------------------RTLIRAGTDAIPLAAGLFSRDIYL 726
              |.|..::.|||||||.:|.                    |.:.|...|.|| :..|..|:.:.
Zfish   525 --YQSHMTLKTSDHKPVSSLLEIGIKVVNEESYKRTFEEIVRQIDRLENDCIP-SVSLSEREFHF 586

  Fly   727 EGMR 730
            :.::
Zfish   587 QDVK 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	98/355 (28%)
inpp5b	XP_009290335.3	INPP5B_PH	6..146	CDD:318889
		INPP5c_INPP5B	253..545	CDD:197327	98/331 (30%)
		PapD-like	574..>648	CDD:317302	4/18 (22%)
		RhoGAP_OCRL1	680..892	CDD:239845

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1399831at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920