Protein Alignment INPP5E and inpp5d

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: XP_021329769.1
• Gene: inpp5d / 559103
• ZFINID: ZDB-GENE-100922-30
• Length: 1108
• Species: Danio rerio
• Alignment Length: 341
• Identity: 103/341 - (30%)
• Similarity: 151/341 - (44%)
• Gaps: 65/341 - (19%)

  Fly   391 ITVFVGTWNMNGHSPPKQLNDFVLPA--------NVEHVP-DIVVMGTQESTPDRFEWEVTIQET 446
            ||:|||||||...:||:.:..:....        ....:| ||.|:||||......||..||:..
Zfish   401 ITIFVGTWNMGNANPPQNITSWFQSKGQGKTHDDTANQIPHDIYVIGTQEDPLGEKEWIETIRGA 465

  Fly   447 LGP-SHVLFH--AT-TLGTLHLAVYMRRDLIWYCSVPEDA-------SMSVRTG--SAFRTKGAV 498
            |.. :::.|.  || ||.::.:.|..:         ||..       |.||:||  :|...||||
Zfish   466 LRDITNISFKQIATQTLWSIRIVVLAK---------PEHENRFSHIFSDSVKTGIANALGNKGAV 521

  Fly   499 AISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNVFWC 563
            .:||....||..||.||||:..:|...|..:...|:..|    ||.:::....|:|..|.::||.
Zfish   522 GVSFMFNRTSFGFVNSHLTSGSEKKLRRNQNYVSILRFL----NLGDKKVNPFDITHRFTHLFWL 582

  Fly   564 GDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKY 628
            ||||:|:..|..:    .:|....:........:..|||.....:...|..::|..|||.|||::
Zfish   583 GDLNYRVDLPSHE----AENIVMKIKQQQYKELLAQDQLKIEKDEEKVFLEYVEEEITFAPTYRF 643

  Fly   629 DPGSQN-------FDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDS 686
            :..::.       ..|.:|...|::.||:|   |:...||                ||.|..|..
Zfish   644 ERDTRERYAYTKAKATGTKYNLPSWCDRVL---RKSYPLV----------------HVVCNSYGC 689

  Fly   687 VPSITTSDHKPVWALF 702
            ...|.||||.||:|.|
Zfish   690 TNDIMTSDHSPVFATF 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	103/341 (30%)
inpp5d	XP_021329769.1	SH2_SHIP	3..105	CDD:198206
		EEP	401..707	CDD:469791	103/341 (30%)
		PHA03378	<935..>1088	CDD:223065