Protein Alignment INPP5E and Inpp5d

DIOPT Version :9

• Sequence 1: NP_001261753.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_062184.2
• Gene: Inpp5d / 54259
• RGDID: 2914
• Length: 1190
• Species: Rattus norvegicus
• Alignment Length: 545
• Identity: 142/545 - (26%)
• Similarity: 224/545 - (41%)
• Gaps: 138/545 - (25%)

  Fly   213 RPRPSSECASAPESPVAS----KTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRL- 272
            ||||.....:.|.:.||.    .:..:.......:.....|||...||.|.|:........|.:
  Rat   249 RPRPQVPGEANPITMVAKLSQLTSLLSSIEDKVKALLHEGSESTNRRSLIPPVTFEVKSESLGIP 313

  Fly   273 -KLYPPGQELPPLQAATEPGD--IKRATTPQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQ 334
             |::        |:...|.|.  ||::.              ||.|.       :|.||:.:.
  Rat   314 QKMH--------LKVDVESGKLIIKKSR--------------DGSED-------KFYSHKKIL-- 347

  Fly   335 RQGSGSNLARQTLMAAHALN--LIPADNARER--------SYLDGRLGSTSLLGPSELSRVLPQK 389
                      |.:.:...||  :|..:..:|:        |....|.|...||...: ::...|.
  Rat   348 ----------QLIKSQKFLNKLVILVETEKEKILRKEYVFSDSKKREGFCQLLQQMK-NKHSEQS 401

  Fly   390 E---ITVFVGTWNMNGHSPPKQLNDFVLPA--------NVEHVP-DIVVMGTQESTPDRFEWEVT 442
            |   ||:|:|||||....|||::..:.|..        :.:::| ||.|:||||......||...
  Rat   402 EPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLGEKEWLEI 466

  Fly   443 IQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSV-----PEDASM-------SVRTGSA--FR 493
            ::      |.|...|::....:|::    .:|...:     ||..:.       :|:||.|  ..
  Rat   467 LR------HSLQEVTSMTFKTVAIH----TLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLG 521

  Fly   494 TKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFD 558
            .||||.:||...|||:.||.||||:..:|...|..:...|:..|    .|.:::....::|..|.
  Rat   522 NKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFL----ALGDKKLSPFNITHRFT 582

  Fly   559 NVFWCGDLNFRLGEP---REKLLEWIQNTKF-PLPSHLPHGYMHTDQLTSVLADGAAFRGFMEAN 619
            ::||.||||:|:..|   .|.:::.|:..:: .|.:|        |||.....:...|..|.|..
  Rat   583 HLFWLGDLNYRVELPTWEAEAIIQKIKQQQYSDLLAH--------DQLLLERKEQKVFLHFEEEE 639

  Fly   620 ITFPPTYKYDPGSQNFDTSSKQRA-------PAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQP 677
            |||.|||:::..:::....:||:|       |::.||:|:|                  |.|. .
  Rat   640 ITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWK------------------SYPL-V 685

  Fly   678 HVQCLLYDSVPSITTSDHKPVWALF 702
            ||.|..|.|...|.||||.||:|.|
  Rat   686 HVVCQSYGSTSDIMTSDHSPVFATF 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	105/353 (30%)
Inpp5d	NP_062184.2	SH2_SHIP	4..105	CDD:198206
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..130
		SH3-binding 1	126..131
		INPP5c_SHIP1-INPP5D	406..712	CDD:197334	103/346 (30%)
		NPXY motif 1	914..917
		PTZ00449	<930..>1132	CDD:185628
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	946..1190
		SH3-binding 2	969..974
		Interaction with DAB2. /evidence=ECO:0000250	1014..1028
		NPXY motif 2	1017..1020
		SH3-binding 3	1038..1049

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810