DRSC/TRiP Functional Genomics Resources

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Protein Alignment INPP5E and Inpp5d

DIOPT Version :10

Sequence 1:NP_648566.1 Gene:INPP5E / 39404 FlyBaseID:FBgn0036273 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_062184.2 Gene:Inpp5d / 54259 RGDID:2914 Length:1190 Species:Rattus norvegicus


Alignment Length:544 Identity:143/544 - (26%)
Similarity:223/544 - (40%) Gaps:136/544 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 RPRPSSECASAPESPVAS----KTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRL- 272
            ||||.....:.|.:.||.    .:..:.......:.....|||...||.|.|:........|.: 
  Rat   249 RPRPQVPGEANPITMVAKLSQLTSLLSSIEDKVKALLHEGSESTNRRSLIPPVTFEVKSESLGIP 313

  Fly   273 -KLYPPGQELPPLQAATEPGD--IKRATTPQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQ 334
             |::        |:...|.|.  ||::.              ||.|.       :|.||:.:.  
  Rat   314 QKMH--------LKVDVESGKLIIKKSR--------------DGSED-------KFYSHKKIL-- 347

  Fly   335 RQGSGSNLARQTLMAAHALN--LIPADNARER--------SYLDGRLGSTSLLGPSELSRVLPQK 389
                      |.:.:...||  :|..:..:|:        |....|.|...||...: ::...|.
  Rat   348 ----------QLIKSQKFLNKLVILVETEKEKILRKEYVFSDSKKREGFCQLLQQMK-NKHSEQS 401

  Fly   390 E---ITVFVGTWNMNGHSPPKQLNDFVLPA--------NVEHVP-DIVVMGTQESTPDRFEW-EV 441
            |   ||:|:|||||....|||::..:.|..        :.:::| ||.|:||||......|| |:
  Rat   402 EPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLGEKEWLEI 466

  Fly   442 ---TIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASM-------SVRTGSA--FRT 494
               ::||....:.......||..:.:.|..:         ||..:.       :|:||.|  ...
  Rat   467 LRHSLQEVTSMTFKTVAIHTLWNIRIVVLAK---------PEHENRISHICTDNVKTGIANTLGN 522

  Fly   495 KGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDN 559
            ||||.:||...|||:.||.||||:..:|...|..:...|:..|    .|.:::....::|..|.:
  Rat   523 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFL----ALGDKKLSPFNITHRFTH 583

  Fly   560 VFWCGDLNFRLGEP---REKLLEWIQNTKF-PLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANI 620
            :||.||||:|:..|   .|.:::.|:..:: .|.:|        |||.....:...|..|.|..|
  Rat   584 LFWLGDLNYRVELPTWEAEAIIQKIKQQQYSDLLAH--------DQLLLERKEQKVFLHFEEEEI 640

  Fly   621 TFPPTYKYDPGSQNFDTSSKQRA-------PAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPH 678
            ||.|||:::..:::....:||:|       |::.||:|:|                  |.|. .|
  Rat   641 TFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWK------------------SYPL-VH 686

  Fly   679 VQCLLYDSVPSITTSDHKPVWALF 702
            |.|..|.|...|.||||.||:|.|
  Rat   687 VVCQSYGSTSDIMTSDHSPVFATF 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INPP5ENP_648566.1 EEP 387..703 CDD:469791 106/352 (30%)
Inpp5dNP_062184.2 SH2_SHIP 4..105 CDD:198206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..130
SH3-binding 1 126..131
INPP5c_SHIP1-INPP5D 406..712 CDD:197334 104/345 (30%)
NPXY motif 1 914..917
PTZ00449 <930..>1132 CDD:185628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..1190
SH3-binding 2 969..974
Interaction with DAB2. /evidence=ECO:0000250 1014..1028
NPXY motif 2 1017..1020
SH3-binding 3 1038..1049
Blue background indicates that the domain is not in the aligned region.

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