DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and INPP5K

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_057616.2	Gene:	INPP5K / 51763	HGNCID:	33882	Length:	448	Species:	Homo sapiens

Alignment Length:	387	Identity:	110/387 - (28%)
Similarity:	156/387 - (40%)	Gaps:	80/387 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 LGSTSLLGPSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE---- 431
            :.|..|.||.       .:.:::.|.|||:...:||..|:|.:...|.....||.|:|.||
Human     1 MSSRKLSGPK-------GRRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELNSG 58

  Fly   432 ------STPDRFEWEVTIQETLGP------SHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASM 484
                  .......|...:.:.|.|      |||......|  |..|.|.....|...|     :.
Human    59 IISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILL--LVFAKYQHLPYIQILS-----TK 116

  Fly   485 SVRTG--SAFRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLP-RNLPNQ 546
            |..||  ..:..||.|.|...|:|..:..:..||..|.....:|:....||:...:.. |::||
Human   117 STPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPN- 180

  Fly   547 RHKNKDVTQNFDNVFWCGDLNFRLGE-----PREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVL 606
                   ..:.|.:.|.||:|||:.:     .||.    |:|..:       .|....|||:...
Human   181 -------ILDHDLIIWFGDMNFRIEDFGLHFVRES----IKNRCY-------GGLWEKDQLSIAK 227

  Fly   607 ADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGV 671
            ......|.|.|..:.||||||:|..|.::|||.|:|.||:|||||::        ::||... |.
Human   228 KHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWR--------LKRQPCA-GP 283

  Fly   672 STPTQP--HVQCLL--YDSVPSITTSDHKPVWALF----RTLIRAGTDAIPLAAGLFSRDIY 725
            .||..|  |....|  |.|..:...||||||...|    :.|:.|     ||.. |...|::
Human   284 DTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSA-----PLIV-LMPEDLW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	100/347 (29%)
INPP5K	NP_057616.2	EEP	14..320	CDD:382041	100/340 (29%)
		Catalytic. /evidence=ECO:0000255	16..318		99/336 (29%)
		Required for interaction with GPR78 and PAK1. /evidence=ECO:0000269\|PubMed:26940976	318..448		7/28 (25%)
		Required for ruffle localization	321..448		6/25 (24%)
		SKICH	331..431	CDD:375315	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810