DRSC/TRiP Functional Genomics Resources

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Protein Alignment INPP5E and SH2D1A

DIOPT Version :9

Sequence 1:NP_001261753.1 Gene:INPP5E / 39404 FlyBaseID:FBgn0036273 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_002342.1 Gene:SH2D1A / 4068 HGNCID:10820 Length:128 Species:Homo sapiens


Alignment Length:89 Identity:18/89 - (20%)
Similarity:33/89 - (37%) Gaps:31/89 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   592 LPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQ 656
            |.|||::|.:::..                       :.||.:.:|     ||....|.   :|:
Human    46 LYHGYIYTYRVSQT-----------------------ETGSWSAET-----APGVHKRY---FRK 79

  Fly   657 MQGLVIRRQTLVPGVSTPTQPHVQ 680
            ::.|:...|....|:..|.|..|:
Human    80 IKNLISAFQKPDQGIVIPLQYPVE 103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INPP5ENP_001261753.1 EEP 387..703 CDD:321002 18/89 (20%)
SH2D1ANP_002342.1 SH2_SAP1a 2..104 CDD:198263 18/89 (20%)
Interaction with FYN SH3 domain. /evidence=ECO:0000250|UniProtKB:O88890 67..92 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..128
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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