DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and Synj

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster

Alignment Length:	442	Identity:	137/442 - (30%)
Similarity:	192/442 - (43%)	Gaps:	117/442 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 QGSGSNLARQTLMAAHAL--NLIPADNARERSYLDGRLGST---------SLLGPSEL----SRV 385
            || ||.|......||..:  ||:  ||:::.:.....:|||         .:|.||.:    :.|
  Fly   460 QG-GSKLMDGARSAARTIQNNLL--DNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTV 521

  Fly   386 LPQ--KEIT---------VFVGTWNMNG--------------------H--SPPKQLNDFVLPA- 416
            |.:  |..|         |.|||:|:||                    |  :..|.|.|...|:
  Fly   522 LRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSE 586

  Fly   417 NVEHVPDIVVMGTQE------------STPDRFEWEVTIQETLG--PSHVLFHATTLGTLHLAVY 467
            ||:|..||..:|.:|            ||.:...|...:|:|:.  ..:||.....|..:.|.:|
  Fly   587 NVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIY 651

  Fly   468 MR-------RDLIWYCSVPEDASMSVRT--GSAFRTKGAVAISFCLFGTSMLFVTSHLTAHQQKV 523
            :|       ||:...|         |:|  |.|...|||.||.|.|.||||.||.:|..|.|.:|
  Fly   652 IRPEHAPHIRDVAIDC---------VKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQV 707

  Fly   524 KERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPL 588
            .||.:|...|...|..|.....:.|         |.||||||.|:|:...:::|.|.::|
  Fly   708 AERNADYAEITRKLAFPMGRTLKSH---------DWVFWCGDFNYRIDMEKDELKECVRN----- 758

  Fly   589 PSHLPHGYMHT----DQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDR 649
                  |.:.|    |||......|..|..|:|..|||.||||||..|.::|||.||||||:|||
  Fly   759 ------GDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDR 817

  Fly   650 ILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWAL 701
            :|::         ||:.|..|....:..:...|::.....:..|||:||.|:
  Fly   818 VLWR---------RRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAI 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	118/376 (31%)
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	116/361 (32%)
		DUF1866	862..1008	CDD:286093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740