DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and INPPL1

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_024304269.1	Gene:	INPPL1 / 3636	HGNCID:	6080	Length:	1324	Species:	Homo sapiens

Alignment Length:	807	Identity:	187/807 - (23%)
Similarity:	290/807 - (35%)	Gaps:	197/807 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSAGSEERITSSTSSPRSGHKTASSLFGLLSKRPSKVEPHPVTPESPRLQQRPVSACGQYDVSFA 68
            :|.|.:|:   ....||||..:.|:..|     ||...|.|.||.:|..::......||  ||..
Human   131 ASDGEDEK---PPLPPRSGSTSISAPTG-----PSSPLPAPETPTAPAAERDGAEVLGQ--VSRT 185

  Fly    69 KCNADTSANHVNNNGSTLK------SQTLPLEKSHSGLISF-HRRAKPSSSKGKNHSHRHSTDAG 126
            ..:..|......|..||:.      |..|.||....|.... |.....::|..:.||......:|
Human   186 STDFLTPPQSAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSG 250

  Fly   127 SQSDGGADVVMRRKSPKHRSPNHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSNSVLRRDNLS 191
            .:       ::.:...:..||...|...|.:|....|::  ...:.::.:.:.|..|.:::..|.
Human   251 LE-------ILSKVFDQQSSPMVTRLLQQQNLPQTGEQE--LESLVLKLSVLKDFLSGIQKKALK 306

  Fly   192 LSWSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAAS-ASVARSESLQNR 255
            ....|            .|:..|.|......|...||  :.|.......... ..:.:|:..
Human   307 ALQDM------------SSTAPPAPQPSTRKAKTIPV--QAFEVKLDVTLGDLTKIGKSQKF--- 354

  Fly   256 SPIRPMAVSACRSRL-RLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGI----- 314
                .::|.....|| .|:.....||              ..||..|          |.|
Human   355 ----TLSVDVEGGRLVLLRRQRDSQE--------------DWTTFTH----------DRIRQLIK 391

  Fly   315 -EHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLLG 378
             :.::.:.||.|...::.| ||:......||:.......|.|:...::::..
Human   392 SQRVQNKLGVVFEKEKDRT-QRKDFIFVSARKREAFCQLLQLMKNKHSKQDE------------- 442

  Fly   379 PSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFV-----------LPANVEHVPDIVVMGTQES 432
                    |.. |:||:|||||....|||.:..:.           :...:.|  ||.|.||||:
Human   443 --------PDM-ISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPH--DIYVFGTQEN 496

  Fly   433 TPDRFEW----EVTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPED-------ASMSV 486
            :....||    ...::|.....:......:|..:.:||.::         ||.       ::.||
Human   497 SVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVK---------PEHENRISHVSTSSV 552

  Fly   487 RTGSA--FRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHK 549
            :||.|  ...||||.:||...|||..||..|||:..:|...|..:...|:..|.|     ..|..
Human   553 KTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSL-----GDRQL 612

  Fly   550 NK-DVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKF-PLPSHLPHGYMHTDQLTSVLADGAAF 612
            |. |::..|.::||.||||:||....:::|.:|...:| ||        :..|||.........|
Human   613 NAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPL--------LRVDQLNLEREKHKVF 669

  Fly   613 RGFMEANITFPPTYKYDPGSQNFDTSSKQR-------APAYTDRILYKY---------------- 654
            ..|.|..|:|||||:|:.||::.....||:       .|::.||||:|.
Human   670 LRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGQSLP 734

  Fly   655 -RQMQGLVIRRQTLVPGVST--------PTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGT 710
             |.|..|......|.|.:..        |..||...|.......|.||||.||:..|.
Human   735 DRVMGDLGWSPSGLCPNLGRWEPRVGIFPLSPHSYPLSPGCTDDIVTSDHSPVFGTFE------- 792

  Fly   711 DAIPLAAGLFSRDIYLEGMRRRLNNQY 737
                  .|:.|:.|..:|:.:..:..|
Human   793 ------VGVTSQFISKKGLSKTSDQAY 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	108/373 (29%)
INPPL1	XP_024304269.1	SH2_SHIP	17..119	CDD:198206
		EEP	446..793	CDD:321002	108/383 (28%)
		Atrophin-1	<965..1280	CDD:331285
		SAM_Ship2	1260..1322	CDD:188890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810