DRSC/TRiP Functional Genomics Resources

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Protein Alignment INPP5E and INPP5D

DIOPT Version :9

Sequence 1:NP_001261753.1 Gene:INPP5E / 39404 FlyBaseID:FBgn0036273 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_001017915.1 Gene:INPP5D / 3635 HGNCID:6079 Length:1189 Species:Homo sapiens


Alignment Length:752 Identity:176/752 - (23%)
Similarity:277/752 - (36%) Gaps:231/752 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SSAGSEERITSSTSSPRSGHKTASSLFGLLSKRPSKVEPHPVTPESPRLQQRPVSACGQYDVSFA 68
            :|:...:.:..|..:||:...:..||...|.:|...::...:..|..:..|..:|.....|..|.
Human   135 ASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQDSEFV 199

  Fly    69 KCNADTSANHVNNNGSTLKSQTLPLEKSHSGLISFHRRAKPSSSKGKNHSHRHSTDAGSQSDGGA 133
            | ...:|..|:.      |..||..::.:..:|    |..||...                    
Human   200 K-TGSSSLPHLK------KLTTLLCKELYGEVI----RTLPSLES-------------------- 233

  Fly   134 DVVMRRKSPKHRSPNHNRFSHQFSLCCKAEKKPMTP----PVTVRYNSIPDSNSVLRRDNL-SLS 193
               ::|...:..||.             ...:|..|    |:          |.|.:...| ||.
Human   234 ---LQRLFDQQLSPG-------------LRPRPQVPGEANPI----------NMVSKLSQLTSLL 272

  Fly   194 WSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRSPI 258
            .|:.|.....||....|.|||           |.:...||            ..::|||      
Human   273 SSIEDKVKALLHEGPESPHRP-----------SLIPPVTF------------EVKAESL------ 308

  Fly   259 RPMAVSACRSRLRLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGIEHIEEQPGV 323
                  ....:::||:            ..|.|.:            .|....||.|.       
Human   309 ------GIPQKMQLKV------------DVESGKL------------IIKKSKDGSED------- 336

  Fly   324 RFMSHENMTLQRQGSGSNLARQTLMAAHALN----LIPADN----ARERSYLDG--RLGSTSLLG 378
            :|.||:.:.            |.:.:...||    |:..:.    .:|..:.|.  |.|...||.
Human   337 KFYSHKKIL------------QLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQ 389

  Fly   379 PSELSRVLPQKE---ITVFVGTWNMNGHSPPKQLNDFVLPA--------NVEHVP-DIVVMGTQE 431
            ..: ::...|.|   ||:|:|||||....|||::..:.|..        :.:::| ||.|:||||
Human   390 QMK-NKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQE 453

  Fly   432 STPDRFEWEVTIQETLGP-SHVLFHATTLGTLHLAVYMRRDLIWYCSV-----PEDASM------ 484
            ......||...::.:|.. :.|.|....:.||           |...:     ||..:.      
Human   454 DPLSEKEWLEILKHSLQEITSVTFKTVAIHTL-----------WNIRIVVLAKPEHENRISHICT 507

  Fly   485 -SVRTGSA--FRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQ 546
             :|:||.|  ...||||.:||...|||:.||.||||:..:|...|..:...|:..|    .|.::
Human   508 DNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFL----ALGDK 568

  Fly   547 RHKNKDVTQNFDNVFWCGDLNFRLGEP---REKLLEWIQNTKF-PLPSHLPHGYMHTDQLTSVLA 607
            :....::|..|.::||.||||:|:..|   .|.:::.|:..:: .|.||        |||.:...
Human   569 KLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSH--------DQLLTERR 625

  Fly   608 DGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRA-------PAYTDRILYKYRQMQGLVIRRQ 665
            :...|..|.|..|||.|||:::..:::....:||:|       |::.||:|:|            
Human   626 EQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWK------------ 678

  Fly   666 TLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALF 702
                  |.|. .||.|..|.|...|.||||.||:|.|
Human   679 ------SYPL-VHVVCQSYGSTSDIMTSDHSPVFATF 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INPP5ENP_001261753.1 EEP 387..703 CDD:321002 107/354 (30%)
INPP5DNP_001017915.1 SH2_SHIP 1..102 CDD:198206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..132
SH3-binding 1 124..129
INPP5c_SHIP1-INPP5D 404..710 CDD:197334 105/347 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..906
PHA03307 899..>1127 CDD:223039
NPXY motif 1 912..915
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..1189
SH3-binding 2 969..974
Interaction with DAB2. /evidence=ECO:0000250 1016..1030
NPXY motif 2 1019..1022
SH3-binding 3 1040..1051
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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