DRSC/TRiP Functional Genomics Resources

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Protein Alignment INPP5E and INPP5B

DIOPT Version :10

Sequence 1:NP_648566.1 Gene:INPP5E / 39404 FlyBaseID:FBgn0036273 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_005531.2 Gene:INPP5B / 3633 HGNCID:6077 Length:913 Species:Homo sapiens


Alignment Length:402 Identity:122/402 - (30%)
Similarity:180/402 - (44%) Gaps:89/402 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 MTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLLGPSELSRVLPQKEITVFV 395
            :::|:.|     .|.|::.:|.|.       :|..|       |.:            :....|.
Human   236 LSMQKFG-----LRDTIVKSHLLQ-------KEEDY-------TYI------------QNFRFFA 269

  Fly   396 GTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE-----------STPDRFEWEVTIQETLGP 449
            ||:|:||.||.:.|..::  :|....||:..:|.||           .||...||...:.|.|.|
Human   270 GTYNVNGQSPKECLRLWL--SNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHP 332

  Fly   450 --SHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFR--TKGAVAISFCLFGTSML 510
              .:.......|..:.|.:|::::...|.|  |..:.:|.||...|  .||.|||.|....||:.
Human   333 DAKYAKVKLIRLVGIMLLLYVKQEHAAYIS--EVEAETVGTGIMGRMGNKGGVAIRFQFHNTSIC 395

  Fly   511 FVTSHLTAHQQKVKERVSDVKRIINALDLPR---NLPNQRHKNKDVTQNFDNVFWCGDLNFRLGE 572
            .|.|||.||.::.:.|..|.|.|.:.:...:   :||.....|.||      :.|.||||:|:.|
Human   396 VVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDV------ILWLGDLNYRIEE 454

  Fly   573 -PREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFD 636
             ..||:.:.|:...|    .:.:.|   |||...:|....|.||.|..:||.||||||.||.::|
Human   455 LDVEKVKKLIEEKDF----QMLYAY---DQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWD 512

  Fly   637 TSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWAL 701
            ||.|.||||:.||||:|.:.:                 ||     |.|.|..::.|||||||.::
Human   513 TSEKCRAPAWCDRILWKGKNI-----------------TQ-----LSYQSHMALKTSDHKPVSSV 555

  Fly   702 FRTLIRAGTDAI 713
            |...:|...|.:
Human   556 FDIGVRVVNDEL 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INPP5ENP_648566.1 EEP 387..703 CDD:469791 110/334 (33%)
INPP5BNP_005531.2 INPP5B_PH 1..146 CDD:465268
INPP5c_INPP5B 265..558 CDD:197327 111/331 (34%)
RhoGAP_OCRL1 692..912 CDD:239845
Blue background indicates that the domain is not in the aligned region.

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