DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and Inpp5b

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001094225.1	Gene:	Inpp5b / 362590	RGDID:	1311511	Length:	916	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	129/457 - (28%)
Similarity:	205/457 - (44%)	Gaps:	83/457 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 PLQAATEPGDIKRATTPQHMSSPNI-ATQPD--GIEHIEEQPGVRFMSHENMTLQRQGSG----S 340
            |.:..::|| .:....|......|: :::|:  |:..:::..|.|.......:|.||...    :
  Rat   159 PREWNSDPG-TRSGFAPIGGGGYNVDSSRPNGRGLLPLDQSSGARCPDKPENSLTRQNRSKAEIT 222

  Fly   341 NLARQTLMA----AHALNL--IPADNARERSYLDGRLGSTSLLGPSELSRVLPQKEITVFVGTWN 399
            ::.|.:.:.    ||.|::  ....:...||:|..:.|..:.:           :....||||:|
  Rat   223 DMVRSSTITVSDKAHILSMQKFGLRDTMVRSHLLQKEGEYTYI-----------QNFRFFVGTYN 276

  Fly   400 MNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE-----------STPDRFEWEVTIQETLGP--SH 451
            :||.||.:.|..::  ::....||:..:|.||           .||...||...:.|:|.|  .:
  Rat   277 VNGQSPKECLRPWL--SSDTKAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLHPDAKY 339

  Fly   452 VLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFR--TKGAVAISFCLFGTSMLFVTS 514
            .......|..:.|.:|::::...|.|  |..:.:|.||...|  .||.|||.|.|..||:..|.|
  Rat   340 AKVKLIRLVGIMLLLYVKQEHAAYIS--EVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNS 402

  Fly   515 HLTAHQQKVKERVSDVKRIINALDLPR---NLPNQRHKNKDVTQNFDNVFWCGDLNFRLGE-PRE 575
            ||.||.::.:.|..|.:.|.:.:...:   :||.......||      :.|.||||:|:.| ..|
  Rat   403 HLAAHTEEYERRNQDYRDICSRMQFSQVDPSLPPLTISKHDV------ILWLGDLNYRIEELDVE 461

  Fly   576 KLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSK 640
            |:.:.::...|       |.....|||...:|....|.||.|..|||.||||||.||.|:|||.|
  Rat   462 KVKKLVEEKAF-------HTLYAHDQLKIQVAAKTVFEGFTEGEITFQPTYKYDTGSDNWDTSEK 519

  Fly   641 QRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRTL 705
            .||||:.||:|::.:                      ::..|.|.|..|:.|||||||.::|...
  Rat   520 CRAPAWCDRVLWRGK----------------------NISQLSYQSHMSLKTSDHKPVSSVFEIG 562

  Fly   706 IR 707
            :|
  Rat   563 VR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	107/334 (32%)
Inpp5b	NP_001094225.1	INPP5B_PH	6..150	CDD:293381
		INPP5c_INPP5B	268..561	CDD:197327	108/331 (33%)
		RhoGAP_OCRL1	695..915	CDD:239845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1399831at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820