DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and FIG4

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	87/423 - (20%)
Similarity:	145/423 - (34%)	Gaps:	128/423 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VSFAKCNADTSANHVNNNGSTLKSQTLPLEKSHSGLISFHRRAKPSSSKGKNHSHRHSTDAGSQS 129
            |..||...|:....:..|.......||.|:...|.|:  ||          ..::|.:...|||
  Fly   479 VKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLV--HR----------IKTYRKTAPWGSQ- 530

  Fly   130 DGGADVVMRRKSPKHRSPNHNRFS-----HQFSLCCKAEKKPMT---PPVTV------RYNS-IP 179
              |:| ||:..|..:    .|.||     |..:|.....|..:|   ||:..      .:|: :|
  Fly   531 --GSD-VMQTLSRYY----SNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHNAFVP 588

  Fly   180 DSNS------VLRRDNLSLSWSMVDNN-----------SG----SLHSSEGSSHRPRPSSECASA 223
            .::|      |..:....|.:|..|:|           ||    ..:|:...|.:....||..:.
  Fly   589 RADSKAITDWVRHKVRACLPYSCADSNKLVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAF 653

  Fly   224 PESPVASK---TFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPPGQELPPLQ 285
            ..|.:|.:   ||..:.||.......:| ::.||.|.....:..:..|.               .
  Fly   654 EISQLALRYMPTFRTNFSPFQRQIQTSR-KARQNPSMTGQSSTGSMNSN---------------S 702

  Fly   286 AATEPGD------------IKRATTPQHMSSPNIATQPDGIEHIEEQPG--VRFMSHENMTLQRQ 336
            :::..||            .::.......:.|..||...|:..:||..|  :...|.::|.:.::
  Fly   703 SSSSEGDDSSSDEELSASFAEKEANQTESTEPAAATLATGLPSMEEIYGCTINPPSKQSMAVYKK 767

  Fly   337 -------GSGSNLARQTLMA---------AHALNLIPADNARERSYLDGRLGSTSLLGPSELSRV 385
                   .||.....||.:|         ...:.|.|..:....|||..|            ..|
  Fly   768 YVQMGKLSSGGARPAQTAVAQRDQELAKIMRGITLRPLSDYGTDSYLSVR------------PPV 820

  Fly   386 LPQKEITVFV------GTWNMNGHSPPKQLNDF 412
            :|:|.:|::.      .|:|    :.|| |.:|
  Fly   821 VPRKSLTIYAEYCRTRSTFN----AVPK-LEEF 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	9/32 (28%)
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	33/139 (24%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930