DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and Ocrl

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_796189.2	Gene:	Ocrl / 320634	MGIID:	109589	Length:	900	Species:	Mus musculus

Alignment Length:	456	Identity:	129/456 - (28%)
Similarity:	186/456 - (40%)	Gaps:	113/456 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 EEQPGV-----RFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLL 377
            :|||.|     :.......|.||:|          :..|.|      ..||:.|::
Mouse   196 KEQPKVTNTMRKLFVPNTQTGQREG----------LIKHIL------TKREKEYVN--------- 235

  Fly   378 GPSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE---STPDRF-- 437
                      .:....||||||:||.||...|..: |..: .:.|||..:|.||   ||...|
Mouse   236 ----------IQSFRFFVGTWNVNGQSPDSSLEPW-LDCD-PNPPDIYCIGFQELDLSTEAFFYF 288

  Fly   438 ------EWEVTIQETLGPSHVLFHATTLGTL---HLAVYMRRDLIWYCSVPEDASMSVRTG--SA 491
                  ||.:.::..| ||...:....|..|   .|.::.|:|...|  :.:.|:.:..||  ..
Mouse   289 ESVKEQEWSLAVERGL-PSKAKYRKVQLVRLVGMMLLIFARKDQCQY--IRDVATETTGTGIMGK 350

  Fly   492 FRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQN 556
            ...||.||:.|....|:...|.|||.||.::.:.|..|.|.|...:..  ::|||.....::.::
Mouse   351 MGNKGGVAVRFVFHNTTFCIVNSHLAAHVEEFERRNQDYKDICARMTF--SVPNQTVPQVNIMKH 413

  Fly   557 FDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANIT 621
             |.|.|.||||:||..|....::.:.| |..|     |..:..|||........||..|.|..|.
Mouse   414 -DVVIWLGDLNYRLCMPDASEVKSLIN-KNEL-----HKLLKFDQLNIQRTQKKAFADFNEGEIN 471

  Fly   622 FPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDS 686
            |.||||||..:..:|:|.|.|.||:.||||::                |:      :|..|.|.|
Mouse   472 FVPTYKYDSKTDRWDSSGKCRVPAWCDRILWR----------------GI------NVNQLHYRS 514

  Fly   687 VPSITTSDHKPVWALF--------------------RTLIRAGTDAIPLAAGLFSRDIYLEGMRR 731
            ...:.|||||||.|||                    |.:.|...|.:| :..|..|:.:.|.::.
Mouse   515 HMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVRIMDRMENDFLP-SLELSRREFFFENVKF 578

  Fly   732 R 732
            |
Mouse   579 R 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	108/351 (31%)
Ocrl	NP_796189.2	PH_OCRL1	11..115	CDD:270182
		Clathrin box 1	73..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..201		3/4 (75%)
		5-phosphatase. /evidence=ECO:0000250	236..562		111/361 (31%)
		INPP5c_INPP5B	239..532	CDD:197327	108/328 (33%)
		ASH. /evidence=ECO:0000250	563..677		4/17 (24%)
		RhoGAP_OCRL1	667..895	CDD:239845
		Clathrin box 2	701..705
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1399831at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820