Protein Alignment INPP5E and Ocrl

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 109/355 - (30%)
• Similarity: 159/355 - (44%)
• Gaps: 80/355 - (22%)

  Fly   383 SRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLP-----ANVEHVPDIVVMGTQE-STPDRF---- 437
            |..:..|:|.::..|||:|.    |..:|...|     |..|..|||..:|.|| .||.:.
  Fly   177 SEYIVYKDIIIYCATWNVNN----KTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNS 237

  Fly   438 --------EWEVTIQETLGPS---HVLFHATTLGTLHLAVYMRRDL---IWYCSVPEDASMSVRT 488
                    :|...:.:::.|.   .:|.....:.|: |.|.:|:.|   |..|. |:..:..:
  Fly   238 TQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATM-LTVIVRKQLRQHIIRCR-PKSVARGI-- 298

  Fly   489 GSAFRT---KGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKN 550
               |.|   ||.||||..|...::.||.|||.||...|:||..|...|:..:         |..:
  Fly   299 ---FNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGI---------RFDD 351

  Fly   551 KDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGY---MHTDQLTSVLADGAAF 612
            .....:.|::||.||||:|:.||        ...:.|.|......|   :..|||...:..|..|
  Fly   352 GRTISDHDHIFWVGDLNYRIQEP--------PGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCF 408

  Fly   613 RGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQP 677
            .|:.|..|.|.||||||||:.|:|:|.|||||||.||:|:|                      ..
  Fly   409 EGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWK----------------------GT 451

  Fly   678 HVQCLLYDSVPSITTSDHKPVWALFRTLIR 707
            .::.|.|:|:..|..||||||:|:|:..::
  Fly   452 RIEQLAYNSIMEIRQSDHKPVYAVFQVKVK 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	107/345 (31%)
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268
		INPP5c_INPP5B	185..478	CDD:197327	107/342 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845