DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and Inpp5k

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_006532570.1	Gene:	Inpp5k / 19062	MGIID:	1194899	Length:	472	Species:	Mus musculus

Alignment Length:	365	Identity:	100/365 - (27%)
Similarity:	155/365 - (42%)	Gaps:	66/365 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 YLDGRLGSTSLLGPSELSRVLPQK-EITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGT 429
            |.:|.:.:.||..||     .|:. .::|.|.|||:...:|...|:|.:...|.:...||.::|.
Mouse    11 YREGIMSAVSLRRPS-----APKGFALSVHVVTWNVASAAPTVDLSDLLQLNNQDLNLDIYIIGL 70

  Fly   430 QES--------TPDRFE--WEVTIQETLGP-SHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDAS 483
            ||.        :...||  |.....:.|.| :.|......:..|.|.|:.:...:.|..:....|
Mouse    71 QEMNFGIISLLSDAAFEDPWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKS 135

  Fly   484 MSVRTGSAFRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINAL-----DLPRNL 543
            ........:..||.|.:...|:|..:..:..||..|.....:|:....||:.:|     |:|..|
Mouse   136 TPTGLYGYWGNKGGVNVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNIL 200

  Fly   544 PNQRHKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGY----MHTDQLTS 604
                        :.|.:.|.||:|||:   .:..|.::|.:       :...|    ...|||..
Mouse   201 ------------DHDLILWFGDMNFRI---EDFGLLFVQES-------ITRKYYKELWEKDQLFI 243

  Fly   605 VLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVP 669
            ...:....|.|.|..:.||||||:|..|.|:|||.|:|.||:|||||::        ::||   |
Mouse   244 AKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWR--------LKRQ---P 297

  Fly   670 GVSTP---TQPHVQCLL----YDSVPSITTSDHKPVWALF 702
            ..::|   :.|....||    |.|..:.:.||||||...|
Mouse   298 SQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTF 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	94/344 (27%)
Inpp5k	XP_006532570.1	EEP	32..339	CDD:382041	93/339 (27%)
Inpp5k	XP_006532570.1	SKICH	350..454	CDD:375315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810