Protein Alignment INPP5E and inpp-5K

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_498783.1
• Gene: inpp-5K / 183643
• WormBaseID: WBGene00086546
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 375
• Identity: 91/375 - (24%)
• Similarity: 140/375 - (37%)
• Gaps: 100/375 - (26%)

  Fly   390 EITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQESTPDRFEWEVTIQETLGPSHVLF 454
            :||:|  |:|:...:...:....:|...::....:|.:|.|         ||...||:|.: ||.
 Worm     4 KITIF--TYNLAMKASDSEAVHNMLNGMIDDHTHLVAIGLQ---------EVAHSETIGGA-VLT 56

  Fly   455 HATTL------------------GTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAIS 501
            .|||:                  .|..:.::.|:.||......:........|.....||::.:.
 Worm    57 WATTIASWMNTNGRMVLLAKTFQATNQVLIFGRKQLIGQIKRIDYRFQRNTMGGLTGHKGSIGVR 121

  Fly   502 FCLFGT-SMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDN----VF 561
            ..|... |::||.||.....:...:||                 .|.|.|::.:...|.    .|
 Worm   122 LQLASPYSIVFVDSHFIHGPENYGKRV-----------------EQYHTNRNCSFPEDKSVRAAF 169

  Fly   562 WCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHT-DQLTSVLADGAAFRGFMEANITFPPT 625
            |.||.|||:.|....::..|:|     .:||.  .:.| :||...|.:..||.||.|..:||.||
 Worm   170 WFGDFNFRVEEDVNTVIRKIKN-----GTHLE--LLDTREQLKRALVERDAFIGFHEQPVTFEPT 227

  Fly   626 YKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSI 690
            |:...|:...|   .:|.|::|||||||...:.|                      |.|.:....
 Worm   228 YRVTVGTTEQD---GKRVPSWTDRILYKGDGITG----------------------LSYTNNKKA 267

  Fly   691 TTSDHKPVWALFRTLIRAGT---------------DAIPLAAGLFSRDIY 725
            ..|||.||.|:||....|..               .:|||.......::|
 Worm   268 VASDHLPVVAMFRVTAPAAPKPQWEVIFEHLPTWYTSIPLVGRFQVNELY 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	84/336 (25%)
inpp-5K	NP_498783.1	IPPc	1..284	CDD:214525	86/340 (25%)
		SKICH	293..394	CDD:465482	4/25 (16%)