DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and unc-26

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001023266.1	Gene:	unc-26 / 178284	WormBaseID:	WBGene00006763	Length:	1119	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	112/382 - (29%)
Similarity:	170/382 - (44%)	Gaps:	66/382 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 ALNLIPADNARERSYLDGRLGSTSLLGPSELSRVLPQKEITVFVGTWNMNG----HS----PPKQ 408
            |.|::|....:|..|......:.|.|.........|| .|.:||||||:||    |:    ....
Worm   489 ACNILPPSLIQESYYYHEYADAVSQLVERSPEIAEPQ-SIKIFVGTWNVNGGKNIHNVAFRNESS 552

  Fly   409 LNDFVLPANV--------EHVPDIVVMGTQE------------STPDRFEWEVTIQETLGPS--H 451
            |:.::...::        |.:.|||.:|.:|            ||.::..|..:|::||...  .
Worm   553 LSHWIFANSMTRLVSVEDEQLADIVAIGVEELVDLNASNMVKASTTNQRMWCESIRKTLSEKAPF 617

  Fly   452 VLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAISFCLFGTSMLFVTSHL 516
            ||..:..|..:.|.::.|..:..|......||:....|.|...||:||....:|.||:.|:.||.
Worm   618 VLIGSEQLVGVCLFLFARPRVSPYLKDFAVASVKTGMGGATGNKGSVAFRIVVFSTSICFICSHF 682

  Fly   517 TAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWI 581
            .|.|.::::|..|....:..:..|.......|         |.:||.||.|:|:....:::...:
Worm   683 AAGQNEIRDRNEDFATTLKKIRFPLGREIDSH---------DVIFWLGDFNYRINLSGDEVKNAV 738

  Fly   582 QNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAY 646
            :|..:.       ..:..||||...|.|..|.||.|..:||.||||||..|.::|||.|.||||:
Worm   739 RNGDYA-------KLVENDQLTQQKALGQTFVGFNEGQLTFAPTYKYDTFSDDYDTSEKCRAPAW 796

  Fly   647 TDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFR 703
            |||||:|.::.:|                  ..|.|.||. ..:.||||:||.|:|:
Worm   797 TDRILWKDQRKKG------------------KTQLLSYDR-SELKTSDHRPVGAVFK 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	104/345 (30%)
unc-26	NP_001023266.1	Syja_N	60..336	CDD:280532
		INPP5c_Synj	527..835	CDD:197323	103/343 (30%)
		RRM_SF	850..978	CDD:302621
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910