Protein Alignment INPP5E and inpp-1

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_001255511.1
• Gene: inpp-1 / 177970
• WormBaseID: WBGene00012016
• Length: 432
• Species: Caenorhabditis elegans
• Alignment Length: 328
• Identity: 88/328 - (26%)
• Similarity: 144/328 - (43%)
• Gaps: 35/328 - (10%)

  Fly   381 ELSRVLPQKEITVFVGTWNMN--GHSPPKQLNDFVLPANVEHVPDIVVMGTQE--STPDRFEWE- 440
            ::...:..:::.|...|||:|  |......|...:.....|...||..:..||  ||...|..|
 Worm    97 DVIEAMGDRKLKVCTVTWNINEKGVKILSHLAQKIAERGQEMDSDIFFISLQEIPSTAPTFHEEA 161

  Fly   441 VTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASM-SVRTGSAFRTKGAVAISFCL 504
            :.|.|.:...|.|:.:....:..:.|::|:..:.|...|:.:.: |.......|||||:|:...|
 Worm   162 LRILEPVLNGHRLYLSHRAWSQMVIVFIRQKHLRYAIQPQVSFIASGAMAKPVRTKGAIAVCLRL 226

  Fly   505 FGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNVFWCGDLNFR 569
            :...::.:..||:  ....::|:.|..:::..|..|:......|. ||.....|.|.|.||||||
 Worm   227 YQRFIVLIGCHLS--HATPQQRIQDYAKVVRTLRFPQLARFHAHA-KDEIFGSDVVLWIGDLNFR 288

  Fly   570 LGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQN 634
            :  ..|..::|....|  :..........|::|.|......||..|.||.|.||||:|::|.:.|
 Worm   289 V--TVESNVDWRDPEK--ITEKTFRDVFETEELASHRKKQLAFTDFKEAPIKFPPTHKFEPDTDN 349

  Fly   635 FDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVW 699
            :   ..:|.|::|||:|:..|..:.|                   |.:.||.:...|.||||.|:
 Worm   350 Y---VPKRIPSFTDRVLFWVRNSEWL-------------------QNIQYDCMRGTTPSDHKAVF 392

  Fly   700 ALF 702
            |.|
 Worm   393 ATF 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	88/322 (27%)
inpp-1	NP_001255511.1	IPPc	105..399	CDD:214525	88/320 (28%)