DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and Inppl1

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001116211.1	Gene:	Inppl1 / 16332	MGIID:	1333787	Length:	1257	Species:	Mus musculus

Alignment Length:	786	Identity:	174/786 - (22%)
Similarity:	287/786 - (36%)	Gaps:	247/786 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PRSGHKTASSLFGLLSKRPSKVEPHPVTPESPRLQQRPVSACGQYDVSFAKCNADTSANHVNNNG 83
            ||||..:.|:..|     ||...|.|.||.:|..:..|              |..::.:|....|
Mouse   143 PRSGSTSISAPVG-----PSSPLPTPETPTTPAAESTP--------------NGLSTVSHEYLKG 188

  Fly    84 STLKSQTLPLEKSHSGLISF-HRRAKPSSSKGKNHSHRHSTDAGSQSDGGADVVMRRKSPKHRSP 147
                |..|.||....|..:. |......:|..:.||......:|.:       ::.:...:..||
Mouse   189 ----SYGLDLEAVRGGASNLPHLTRTLVTSCRRLHSEVDKVLSGLE-------ILSKVFDQQSSP 242

  Fly   148 NHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSH 212
            ...|...|.||....|::  ...:.::.:.:.|..|.:::..|.   ::.|.:|
Mouse   243 MVTRLLQQQSLPQTGEQE--LESLVLKLSVLKDFLSGIQKKALK---ALQDMSS----------- 291

  Fly   213 RPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPP 277
                     :||              ||....|:.:::::    |::...|     :|.:.|
Mouse   292 ---------TAP--------------PAPLQPSIRKAKTI----PVQAFEV-----KLDVTL--- 321

  Fly   278 GQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDG----------------------------- 313
                         ||:.:....|..:   ::...:|
Mouse   322 -------------GDLTKIGKSQKFT---LSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIK 370

  Fly   314 IEHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLLG 378
            .:.::.:.||.|...::.| ||:......||:.......|.|:.
Mouse   371 SQRVQNKLGVVFEKEKDRT-QRKDFIFVSARKREAFCQLLQLMK--------------------- 413

  Fly   379 PSELSRVLPQKE---ITVFVGTWNMNGHSPPKQLNDFV-----------LPANVEHVPDIVVMGT 429
                :|...|.|   |:||:|||||....|||.:..:.           :...:.|  ||.|.||
Mouse   414 ----NRHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKALDEVTVTIPH--DIYVFGT 472

  Fly   430 QESTPDRFEW----EVTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPED-------AS 483
            ||::....||    ...::|.....:......:|..:.:||.::         ||.       ::
Mouse   473 QENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVK---------PEHENRISHVST 528

  Fly   484 MSVRTGSA--FRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPR--NLP 544
            .||:||.|  ...||||.:||...|||..||..|||:..:|.      .:|..|.||:.|  :|.
Mouse   529 SSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKT------TRRNQNYLDILRLLSLG 587

  Fly   545 NQRHKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKF-PLPSHLPHGYMHTDQLTSVLAD 608
            :::....|::..|.::||.||||:||....:::|.:|...:| ||        :..|||......
Mouse   588 DRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPL--------LRVDQLNLEREK 644

  Fly   609 GAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQR-------APAYTDRILYKYRQMQGLVIRRQT 666
            ...|..|.|..|:|||||:|:.||::.....||:       .|::.||||:|
Mouse   645 HKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWK------------- 696

  Fly   667 LVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLEGMRR 731
                 |.| :.|:.|..|.....|.||||.||:..|.             .|:.|:.|..:|:.:
Mouse   697 -----SYP-ETHIICNSYGCTDDIVTSDHSPVFGTFE-------------VGVTSQFISKKGLSK 742

  Fly   732 RLNNQY 737
            ..:..|
Mouse   743 TSDQAY 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	105/352 (30%)
Inppl1	NP_001116211.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181		15/56 (27%)
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	104/359 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986
		SH3-binding	945..950
		NPXY motif	984..987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1134..1196
		SAM_Ship2	1193..1255	CDD:188890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810