DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INPP5E and Inpp5b

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_006502867.1	Gene:	Inpp5b / 16330	MGIID:	103257	Length:	994	Species:	Mus musculus

Alignment Length:	581	Identity:	160/581 - (27%)
Similarity:	237/581 - (40%)	Gaps:	143/581 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 PDSNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSSECAS--APESPVASKTFFAHCSPAA 241
            ||:.|...|:     |:.............||.|:.|.:.....  .|..|    .:......||
Mouse   153 PDAESPKPRE-----WNSDPGTRSGFAPIGGSRHQSRNARRGLEDVLPRGP----GYILLWGGAA 208

  Fly   242 ASASVARSESLQNRSPI---RPMAVSACRSRLRLKLYPPGQELPPLQAATEPGDIKRATTPQHMS 303
            .......:|.:....|:   ||:|               |:.    ..|.|..|       ..||
Mouse   209 EEPEFLLAEEMHEGGPVRGRRPLA---------------GRR----DEALEEAD-------WEMS 247

  Fly   304 SPNIATQPD--GIEHIE---------EQP-GVRFMSHENMTLQRQG-SGSNLARQTLMA------ 349
            :...:.:.|  |:.:::         :|| |.|.......:|.||. |.|:::.:...|
Mouse   248 AGGGSRERDCAGVSNVDSSRPNGRGPDQPSGARCPEKPENSLTRQNKSKSDMSEKVRSATVTVSD 312

  Fly   350 -AHALNLIPADNARERSYLDGRLGSTSLLGPSELSRVLPQKE--------ITVFVGTWNMNGHSP 405
             ||.|::             .:.|....:..|.    |.|||        ...||||:|:||.||
Mouse   313 KAHILSV-------------QKFGLRDTIVRSH----LVQKEENYTYIQNFRFFVGTYNVNGQSP 360

  Fly   406 PKQLNDFVLPANVEHVPDIVVMGTQE-----------STPDRFEWEVTIQETLGP----SHVLFH 455
            .:.|..::  ::....||:..:|.||           .||...||...:.|:|.|    :.|.|
Mouse   361 KECLRPWL--SHSALAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLHPDAKYAKVKF- 422

  Fly   456 ATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFR--TKGAVAISFCLFGTSMLFVTSHLTA 518
             ..|..:.|.:|::::...|.|  |..:.:|.||...|  .||.|||.|.|..||:..|.|||.|
Mouse   423 -VRLVGIMLLLYVKQEHAAYIS--EVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSHLAA 484

  Fly   519 HQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQN-FDNVFWCGDLNFRLGE-PREKLLEWI 581
            |.::.:.|..|.:.|.:.:..|:..|:|    ..:|.| .|.:.|.||||:|:.| ...|:.:.:
Mouse   485 HTEEYERRNQDYRDICSRMQFPQVDPSQ----PPLTINKHDVILWLGDLNYRIEELDVGKVKKLV 545

  Fly   582 QNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAY 646
            :...|...      |.| |||...:|....|.||.|..|||.||||||.||.::|||.|.||||:
Mouse   546 EEKAFQTL------YAH-DQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSDDWDTSEKCRAPAW 603

  Fly   647 TDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIR 707
            .||||:|.:.:                 ||     |.|.|..::.|||||||.::|...:|
Mouse   604 CDRILWKGKNI-----------------TQ-----LSYQSHMALKTSDHKPVSSVFDIGVR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	116/342 (34%)
Inpp5b	XP_006502867.1	INPP5B_PH	1..150	CDD:374793
		INPP5c_INPP5B	346..639	CDD:197327	114/331 (34%)
		RhoGAP_OCRL1	773..991	CDD:239845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810