Protein Alignment INPP5E and Inpp5e

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_446084.1
• Gene: Inpp5e / 114089
• RGDID: 620478
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 223/639 - (34%)
• Similarity: 317/639 - (49%)
• Gaps: 106/639 - (16%)

  Fly   157 SLCCKAEKKPMTPPVTVRYN---SIPDSNSVLRRDNLSLSWSMVDNNS----GSLHSSEGSS--- 211
            :|..||......||:..:..   |:.|.....||...|.....|.|.:    |||..|...|
  Rat    66 NLQAKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAY 130

  Fly   212 HRPRPSSECAS-----------APESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVSA 265
            .||.|   |.|           |..|...|.:.::.|    .|..::.|..|.:|.    .|...
  Rat   131 SRPLP---CLSTSLQEIPKPRRATGSEGGSPSLWSDC----LSGMISTSLDLLHRE----AASGG 184

  Fly   266 CRSR---LRLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIAT----QPDGIEHIEEQPGV 323
            ..||   ||....||..:|                   :::|.::.|    .|:..::.......
  Rat   185 PHSRLASLRATHTPPAMDL-------------------NIASSSLRTANKVDPEHTDYKLRMQNR 230

  Fly   324 RFMSHENMTLQRQGS---GSNLARQTLMAAHALNLIP--ADNARERSYLDGR-LGSTSLLGPSEL 382
            ...:|.|:...|..|   |.:.:..:..::.:| |.|  ..:.|.||||:|. |.|.:|||..||
  Rat   231 LVRAHSNLGPSRPRSPLAGDDHSIHSARSSFSL-LAPIRTKDIRSRSYLEGSLLASGALLGADEL 294

  Fly   383 SRVLPQKEITVFVGTWNMNGHSP-PKQLNDFVLPANVEHVPDIVVMGTQESTPDRFEWEVTIQET 446
            :|..|.:.:.:||.||||.|... |..|::|:||...::..|:.|:|.||...||.|||..:|||
  Rat   295 ARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGVQEGCSDRREWETRLQET 359

  Fly   447 LGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAISFCLFGTSMLF 511
            |||.:||..:...|.|::::::||||||:||..|.::::.|..|..:||||:.:||..||||.||
  Rat   360 LGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLF 424

  Fly   512 VTSHLTAHQQKVKERVSDVKRIINALDLPRNLPN---QRHKNKDVTQNFDNVFWCGDLNFRLGEP 573
            :|||.|:...||.||:.|..|.|.||.||||:|:   .|....|||..||.|||.||.||||...
  Rat   425 ITSHFTSGDGKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGG 489

  Fly   574 R---EKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNF 635
            |   |..|:  |:.:..:.:.|.|     ||||..:..|:.|:||.||.|.|.|:||:|.|...:
  Rat   490 RVAVEAFLK--QDPEVDVLALLQH-----DQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTY 547

  Fly   636 DTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWA 700
            |::||||.|:||||:|||.|       .:..:.|            :.|.|.|.|.||||:||:.
  Rat   548 DSTSKQRTPSYTDRVLYKSR-------HKGDICP------------MKYSSCPGIKTSDHRPVYG 593

  Fly   701 LFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLNNQY--------SGASAVCVL 746
            |||..:|.|.|.||||||.|.|::||.|::||::.:.        ..:||||.:
  Rat   594 LFRVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTV 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	138/322 (43%)
Inpp5e	NP_446084.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64
		4 X 4 AA repeats of P-X-X-P	59..243		43/206 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	99..158		16/61 (26%)
		INPP5c_INPP5E-like	299..597	CDD:197329	139/323 (43%)