Protein Alignment INPP5E and inpp5e

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: XP_002935265.1
• Gene: inpp5e / 100486470
• XenbaseID: XB-GENE-29077335
• Length: 607
• Species: Xenopus tropicalis
• Alignment Length: 568
• Identity: 205/568 - (36%)
• Similarity: 295/568 - (51%)
• Gaps: 82/568 - (14%)

  Fly   200 NSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVS 264
            |..||...|.:.     ||..:...||.|..:.   :||.:.:....|:|....|..|
 Frog    96 NQDSLRDPEATG-----SSSGSLQEESAVPDQN---NCSFSDSQGQPAKSGYPGNGKP------- 145

  Fly   265 ACRSRLRLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGIEHIEEQPGVRFMS-- 327
                  ||....|...||.::.......::.|.          ...||.:::.|....:|::.
 Frog   146 ------RLSRILPKHALPQMEINVTSRALRTAN----------RIDPDYMDYQEASSQLRYLRQS 194

  Fly   328 --------HENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGR-LGSTSLLGPSELS 383
                    |.:|...:..|.|..:..:|:..    :.|.| .|.||||:|. |.|.:|||..||.
 Frog   195 SSLSDTRLHSSMVCNQCSSDSMKSTYSLLTP----IRPKD-MRSRSYLEGSLLASGALLGAEELE 254

  Fly   384 RVLPQKEITVFVGTWNMNGHSP-PKQLNDFVLPANVEHVPDIVVMGTQESTPDRFEWEVTIQETL 447
            |..|::.:.||:.||||.|... |:.|:||:||::.:...|:.|:|.||..|||.|||:.:||||
 Frog   255 RYFPERRLGVFIATWNMQGRKELPESLDDFLLPSDDDFAQDMYVIGVQEGCPDRREWEIRLQETL 319

  Fly   448 GPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAISFCLFGTSMLFV 512
            ||.:||.|::..|.|:|:|::||||||:||..|..:::.|..|..:||||:|:||..||||.||:
 Frog   320 GPHYVLLHSSGHGVLYLSVFLRRDLIWFCSEVESDTVTTRIVSQIKTKGALAVSFTFFGTSFLFI 384

  Fly   513 TSHLTAHQQKVKERVSDVKRIINALDLPRNLPN---QRHKNKDVTQNFDNVFWCGDLNFRLGEPR 574
            |||.|:...||.:|:.|.|:||..|.|||.:|:   .|..:.|||..||.|||.||.||||.:.|
 Frog   385 TSHFTSGDSKVCDRILDYKKIIEGLQLPRMIPDTNPYRSNSADVTSRFDEVFWFGDFNFRLNKER 449

  Fly   575 EKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSS 639
            ..:...:|:......|.|    :..||||..:...:.|:||.||.|.|.||||:|.|...:|::|
 Frog   450 SAVNSILQSKLEKDMSRL----LQYDQLTKEMNGESIFKGFQEAEIQFLPTYKFDIGCDVYDSTS 510

  Fly   640 KQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRT 704
            |||.|:||||::||.|.                   :..::.:.|.|...|.||||:||:.||..
 Frog   511 KQRTPSYTDRVVYKSRH-------------------KDDIRVVKYASCSLIKTSDHRPVFGLFEV 556

  Fly   705 LIRAGTDAIPLAAGLFSRDIYLEGMRRR----LNNQYSG----ASAVC 744
            .||.|.|.||||||.|.|::||.|::||    :..:.:|    .|:||
 Frog   557 RIRPGRDNIPLAAGQFDRELYLLGIKRRSTREVQQRQAGKNQKTSSVC 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	137/319 (43%)
inpp5e	XP_002935265.1	INPP5c_INPP5E-like	258..556	CDD:197329	138/320 (43%)