Protein Alignment INPP5E and inpp5jb

DIOPT Version :10

• Sequence 1: NP_648566.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: XP_002662241.3
• Gene: inpp5jb / 100317089
• ZFINID: ZDB-GENE-081104-46
• Length: 657
• Species: Danio rerio
• Alignment Length: 553
• Identity: 140/553 - (25%)
• Similarity: 229/553 - (41%)
• Gaps: 129/553 - (23%)

  Fly   217 SSECASA--PESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPPGQ 279
            |::.||:  |::|       :..||.|..::.||        |.||                  |
Zfish    13 SNDLASSTPPKAP-------SEASPPAVPSAPAR--------PRRP------------------Q 44

  Fly   280 ELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQRQGSGSNLAR 344
            ..|.::.:.:..:.|...:|:    |:...:|:.    |.|..:|.  |......:....:::||
Zfish    45 RSPRVEGSIDVSEPKPPESPK----PSSHDEPNA----EAQAQLRV--HAPPAALKLSGHASVAR 99

  Fly   345 QTL-MAAHALNLIPADNARERSYLDGRLGSTSLLGPSELSRVLPQKEITV--------------- 393
            ..: |.|.:|...|                 |...||..|.|.||:.::|
Zfish   100 SHISMRAASLPQAP-----------------SYKPPSTESVVHPQRALSVAGTADTQPQVAEDFR 147

  Fly   394 -FVGTWNMNGHSPPKQLNDFVLPANV-EHVPDIVVMGTQESTP---DRF-------EWEVTIQET 446
             .:.|||:....||:.:.: :|..|| :...|:.::|.||...   .|.       :|.....:.
Zfish   148 IHIVTWNVGSAMPPEDITN-LLGLNVGDGNTDMYIIGLQEVNSMINKRLKDVLFTDQWSEVCMDA 211

  Fly   447 LGP-SHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRT-----GSAFRTKGAVAISFCLF 505
            |.| .:||..:..:..:.|.|:.:     |..:|....:..:|     |..:..||.|:....:|
Zfish   212 LSPFGYVLATSQRMQGMLLLVFAK-----YFHLPFLRGIQTQTTRTGLGGIWGNKGGVSARMTVF 271

  Fly   506 GTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDN--VFWCGDLNF 568
            |.|:.|:..||.||.:..::|:.|.:.|         |..|:...:..|...|:  |||.|||||
Zfish   272 GHSICFLNCHLPAHMENTEQRMEDFESI---------LQQQQFDGQAATGVLDHDVVFWFGDLNF 327

  Fly   569 RLGEPREKLLEW-IQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGS 632
            |:.:...::::. |.|.|..:       ....|||...........||.|..:.||||||:|.|:
Zfish   328 RIEDLEMQVVKGAIDNNKLSV-------LWEKDQLNIAKDSETVLEGFHEGPLKFPPTYKFDVGT 385

  Fly   633 QNFDTSSKQRAPAYTDRILYKYR---QMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSD 694
            ..:|||.|:|.||:|||||::.|   |:.....:|.:| .|:::.|:  |....|.|....|.||
Zfish   386 DTYDTSGKKRMPAWTDRILWRLRPMAQVSNSTSKRSSL-SGLTSGTR--VSQHFYRSHMEYTVSD 447

  Fly   695 HKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLE 727
            ||||.::|........| :||.. :|..|.:.|
Zfish   448 HKPVSSVFTLQFPYKVD-MPLVT-IFVEDEWRE 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_648566.1	EEP	387..703	CDD:469791	99/354 (28%)
inpp5jb	XP_002662241.3	INPP5c_INPP5J-like	146..457	CDD:197328	97/335 (29%)
		SKICH	468..568	CDD:465482	3/12 (25%)