Protein Alignment INPP5E and sec16a

DIOPT Version :9

• Sequence 1: NP_001261753.1
• Gene: INPP5E / 39404
• FlyBaseID: FBgn0036273
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: XP_004916695.2
• Gene: sec16a / 100216253
• XenbaseID: XB-GENE-986385
• Length: 2362
• Species: Xenopus tropicalis
• Alignment Length: 618
• Identity: 121/618 - (19%)
• Similarity: 178/618 - (28%)
• Gaps: 256/618 - (41%)

  Fly     2 QHSSAGSEERITSSTSSPRS--------GHKTASSLFGLLSKRPSKVEPHPVTPES--------- 49
            ||||           |.|.|        |.....:.|    .:|.|.:.||..|.|
 Frog   260 QHSS-----------SQPPSLNPTDYMHGQNPEQNWF----NQPYKDQRHPPLPSSNPVQYPPPQ 309

  Fly    50 -PRLQQRPVSACGQY--------------------------DVSFAKCNADTSANHVNNNGSTLK 87
             |...|...||.|:.                          |...|...||..::|..|.|....
 Frog   310 QPEPHQEVPSASGRVSTNADSGTISMFFKGEEEENVEIVSSDQQNASIKADLGSSHYQNAGYQGV 374

  Fly    88 SQTLPLEKSHSGLISF----------HRRAKPSSSKGKNHSH---RHSTDAGSQSDGGADVVMRR 139
            |..||.....||:.:.          |   .|||:....|.|   |..|           :.:|.
 Frog   375 SSLLPQPTVSSGIPAMTPITLASGVPH---VPSSAGNATHPHSAWRQDT-----------LPLRD 425

  Fly   140 KSPKHR---------------------SPNHNRFSHQFSLCCKAEKKPMTPPVT---VRYNSIPD 180
            .:.|.|                     .|||      |:        |..|.||   .||..:|.
 Frog   426 NTAKPREMPYDNVENIECVQNQEVLPNEPNH------FN--------PYPPNVTSDAYRYGPVPG 476

  Fly   181 SNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAASAS 245
            .             .:..|.||  |...|      |:.|   .|::        ..|
 Frog   477 P-------------PLPKNVSG--HPEVG------PNLE---TPDT--------VGC-------- 501

  Fly   246 VARSESLQNRSPIRPMAVSACRSRLRLKLYP---PGQE---------------------LPPLQA 286
                       |:||.:||:..|.|.||..|   ..||                     ...:.:
 Frog   502 -----------PVRPDSVSSNYSNLSLKSLPVPTRSQEHAGTFIQKESGRLEGDSSHSFFKQIDS 555

  Fly   287 ATEPGDIKRATTPQH-----MSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQRQGSGSNLARQT 346
            :...||.......||     :|.|...:.|        :|...||:..|.:.:.
 Frog   556 SPMTGDAVGQNMGQHKFHSSLSQPPTPSPP--------KPTGIFMTSANSSFEP----------- 601

  Fly   347 LMAAHALNLIPADNARERSYLDG------RLGSTSLLGPSELSRVLPQKEITVFVGTWNMNG--- 402
             :.:|::.|.|:|  .::|.:.|      :..|..:..|..|.:. |....|:|:|..|.:|
 Frog   602 -VRSHSIGLKPSD--ADQSKMGGEGHKVLQNASIPVASPGNLEQP-PDNLETIFLGKRNSHGTVT 662

  Fly   403 ------HS---PPKQLNDFVLPANVEHVPDIVVMGTQE--STPDRFEWEVTIQETLGPSHVLFHA 456
                  ||   ||......:|    :..|.....|:.:  .:|....|........|.:.:|  |
 Frog   663 SNGSLFHSVGEPPLDNVSLLL----DRRPSSRAQGSSKKCESPATTLWAQGELPNFGGNVLL--A 721

  Fly   457 TTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTG 489
            ....:|::....:.::|   ..|||.|...|.|
 Frog   722 PAAPSLYVPPKPQTEII---QPPEDGSYDSRAG 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	26/117 (22%)
sec16a	XP_004916695.2	PRK12323	<37..>246	CDD:237057
		PHA03247	<719..1172	CDD:223021	10/38 (26%)
		ACE1-Sec16-like	1479..1840	CDD:187750

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2484
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000945
OrthoInspector	1	1.000	-	-		otm47891
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050