DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment INPP5E and inpp5ka

DIOPT Version :9

Sequence 1:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_009290059.1	Gene:	inpp5ka / 100037338	ZFINID:	ZDB-GENE-070410-101	Length:	546	Species:	Danio rerio

Alignment Length:	446	Identity:	122/446 - (27%)
Similarity:	182/446 - (40%)	Gaps:	84/446 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 LQRQGSG--------SNLARQTLMAAHALNLIPADNARERSYLDGRLGST---SLLGPSELSRVL 386
            ||||.|.        |..:||.:....|:.|...|:......|..::..|   :.|...:::...
Zfish    16 LQRQRSDSAASSSTQSTSSRQHVRQRLAMLLTCVDDLDTDHKLQTQVAKTLDEAFLVCRQIAGRP 80

  Fly   387 PQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQE--STPDRF--------EWEV 441
            .:....::|.|||:....||..:| .:|..|....||:.|:|.||  :.|.:|        .|..
Zfish    81 KKNPFRLYVVTWNVATAEPPDDVN-ALLQLNSPKKPDLYVIGLQEVRAAPLKFVSDLAFEDSWSH 144

  Fly   442 TIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCS----VPEDASMSV---RTG--SAFRTKGA 497
            ...:||.|.|.:..:        ::.|:..|:.:.|    ||....:.|   |||  ..:..||.
Zfish   145 LFMDTLSPLHYIKVS--------SIRMQGLLLLFFSKLEHVPFIRDIQVTYTRTGLYGYWGNKGG 201

  Fly   498 VAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDN--V 560
            |.|....:|..:.|:..|||||.....:||.:.:.|::|         |....|:.....|:  |
Zfish   202 VTIRLSFYGHMLCFLNCHLTAHMNYASQRVDEFEHILDA---------QNFNTKNTPHVLDHKVV 257

  Fly   561 FWCGDLNFRLGEPREKLL--EWIQNTKFPL--PSHLPHGYMHTDQLTSVLADGAAFRGFMEANIT 621
            ||.||||||: |....|.  ..|.:.:|.|  |.         ||||.:.......:.|.|..:.
Zfish   258 FWFGDLNFRI-EDHGMLFVRNCITSQRFNLLWPK---------DQLTMMKQKEVILQKFEEGPLD 312

  Fly   622 FPPTYKYDPGSQNFDT---------SSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQP 677
            |.||||:|..|.|:||         :.|:|.||:.||||::.:....|........|......:.
Zfish   313 FQPTYKFDLNSDNYDTRVQTTWFGFNGKKRKPAWCDRILWRVKPKASLTENTNEEEPEKQQEEER 377

  Fly   678 HVQCLL------YDSVPSITTSDHKPVWALFRTLIRAGTDAIPL----AAGLFSRD 723
            ..:..|      |.|......||||||..:||..:|...:. ||    |.|.:|.|
Zfish   378 EDEFPLKMTQEYYTSKMEYGISDHKPVIGIFRLELRKMYET-PLVQVFAEGEWSAD 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	99/355 (28%)
inpp5ka	XP_009290059.1	INPP5c_INPP5J-like	85..410	CDD:197328	100/352 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910