DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sms and sms

DIOPT Version :9

Sequence 1:	NP_001287045.1	Gene:	Sms / 39403	FlyBaseID:	FBgn0036272	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_571831.1	Gene:	sms / 80872	ZFINID:	ZDB-GENE-040625-150	Length:	360	Species:	Danio rerio

Alignment Length:	368	Identity:	151/368 - (41%)
Similarity:	218/368 - (59%)	Gaps:	15/368 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAQTILFDFTLDKDKTADEEARLQVAKILRNELEQLFPQLELAYSMESPE-NGYFAVLHENKDT 64
            ||......||.|        .|...|:..:|. |:.:|.:.|:..::...| :||.|........
Zfish     1 MAVLHYTLDFKL--------RAPADVSATVRG-LQSIFQEQEMTENVHDSEGHGYLATFIGKNSR 56

  Fly    65 VITCRIFQHGLLTLNVEYFLPDGKEPSISFDTMRTMELILRQKFDSD--RSKYLPPIKRGGYIDI 127
            ....|:..|||:|.:::..  :|.:.:...:.:..:|..|:...|.:  |.|.||.:.||..:|.
Zfish    57 FAILRMHSHGLVTFDLQCL--EGDDAAQVDNLLNALEKKLKALLDGNIQRIKRLPALIRGSDVDR 119

  Fly   128 YMTSSDERIIEYDIDKVVFEARSPFQKIQIMHSKTLGNMLLLDELQNIAESDLIYTETLMCRGVE 192
            |..::|.|::|||||:||:|..|.:|.|:|:||:..||||:|:...|:|||||.||:.:|..|.|
Zfish   120 YWPTADGRLMEYDIDEVVYEKDSAYQNIKILHSRQFGNMLILNGDVNLAESDLPYTQAIMGSGKE 184

  Fly   193 NYEGKEICILGGGDGALLYELLKENPKHVVMLEIDELVMQTCNKYLNVICGDVLEKRKGDQYEII 257
            :|.|||:.|||||||.:|:|.:|..||.:.|:||||||:..|.|::...||:||:..|||.|||:
Zfish   185 HYAGKEVLILGGGDGGILHEAVKLKPKMITMVEIDELVIDGCRKHMRKTCGNVLDNLKGDCYEIL 249

  Fly   258 VGDCVEYLKKFIAEGRKFDYVFGDLTDIPITDAPEGE-TWDFIRTIFEHSFKVLKPDGKYLTHGN 321
            |.|||..||||..:||.||||..|||.:||:.|||.: ||:|:|.|.:.|.:||:|.|||.|.||
Zfish   250 VQDCVPVLKKFAEQGRTFDYVINDLTAVPISTAPEEDSTWEFLRLILDLSIRVLRPGGKYFTQGN 314

  Fly   322 GSTCKVQLRLFEEQLNLLRPKVKFTTTKAFVPSFMEEWLFYQV 364
            .......|..:|:.|..|..||.|:.....|||:||.|:||.:
Zfish   315 CVNLTDALSEYEKLLGRLSCKVDFSKEVVCVPSYMELWVFYTI 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sms	NP_001287045.1	AdoMet_MTases	137..362	CDD:302624	115/225 (51%)
sms	NP_571831.1	Spermine_synth	112..360	CDD:279850	123/246 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596199
Domainoid	1	1.000	187	1.000	Domainoid score	I3270
eggNOG	1	0.900	-	-		E1_COG0421
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88709
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2994
OMA	1	1.010	-	-		QHG52515
OrthoDB	1	1.010	-	-		D1243182at2759
OrthoFinder	1	1.000	-	-		FOG0007845
OrthoInspector	1	1.000	-	-		oto40225
orthoMCL	1	0.900	-	-		OOG6_108489
Panther	1	1.100	-	-	LDO	PTHR46315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5650
SonicParanoid	1	1.000	-	-		X5802
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800