DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sms and SMS

DIOPT Version :9

Sequence 1:	NP_001287045.1	Gene:	Sms / 39403	FlyBaseID:	FBgn0036272	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_016885242.1	Gene:	SMS / 6611	HGNCID:	11123	Length:	369	Species:	Homo sapiens

Alignment Length:	381	Identity:	159/381 - (41%)
Similarity:	228/381 - (59%)	Gaps:	28/381 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAQTILFDFTLDKDKTADEEARLQVAKILRNELEQLFPQLELAYSMES-PENGYFAVLHENKDTV 65
            ||:....||.|  ...||.|.      ||:. |:.:|.:..:|.|:.: .::||.|.......:.
Human     3 AARHSTLDFML--GAKADGET------ILKG-LQSIFQEQGMAESVHTWQDHGYLATYTNKNGSF 58

  Fly    66 ITCRIFQHGLLTLNVEYFLPD--GKEPSISFDTM------RTMELILRQKFDSDRSKYLPPIKRG 122
            ...||:.|||:.|:::.:..|  |||   ..|::      |..||   .:..:.|.|.||||.||
Human    59 ANLRIYPHGLVLLDLQSYDGDAQGKE---EIDSILNKVEERMKEL---SQDSTGRVKRLPPIVRG 117

  Fly   123 GYIDIYMTSSDERIIEYDIDKVVFEARSPFQKIQIMHSKTLGNMLLLDELQNIAESDLIYTETLM 187
            |.||.|..::|.|::|||||:||::..||:|.|:|:|||..||:|:|....|:|||||.||..:|
Human   118 GAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIM 182

  Fly   188 CRGVENYEGKEICILGGGDGALLYELLKENPKHVVMLEIDELVMQTCNKYLNVICGDVLEKRKGD 252
            ..|.|:|.||::.|||||||.:|.|::|..||.|.|:|||::|:..|.||:...|||||:..|||
Human   183 GSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGD 247

  Fly   253 QYEIIVGDCVEYLKKFIAEGRKFDYVFGDLTDIPITDAPEGE-TWDFIRTIFEHSFKVLKPDGKY 316
            .|::::.||:..||::..|||:||||..|||.:||:.:||.: ||:|:|.|.:.|.||||.||||
Human   248 CYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKY 312

  Fly   317 LTHGNGSTCKVQLRLFEEQLNLLRPKVKFTTTKAFVPSFMEEWLFYQVTFAXQAQV 372
            .|.||.......|.|:||||..|...|:|:.....|||::|   .|.:|.. ..|:
Human   313 FTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLE---LYPLTVTFCCQI 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sms	NP_001287045.1	AdoMet_MTases	137..362	CDD:302624	111/225 (49%)
SMS	XP_016885242.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159921
Domainoid	1	1.000	189	1.000	Domainoid score	I3305
eggNOG	1	0.900	-	-		E1_COG0421
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88709
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2894
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52515
OrthoDB	1	1.010	-	-		D1243182at2759
OrthoFinder	1	1.000	-	-		FOG0007845
OrthoInspector	1	1.000	-	-		oto91243
orthoMCL	1	0.900	-	-		OOG6_108489
Panther	1	1.100	-	-	LDO	PTHR46315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5650
SonicParanoid	1	1.000	-	-		X5802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800