Protein Alignment Sms and SMS

DIOPT Version :10

• Sequence 1: NP_001287045.1
• Gene: Sms / 39403
• FlyBaseID: FBgn0036272
• Length: 458
• Species: Drosophila melanogaster
• Sequence 2: NP_004586.2
• Gene: SMS / 6611
• HGNCID: 11123
• Length: 366
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 160/373 - (42%)
• Similarity: 228/373 - (61%)
• Gaps: 25/373 - (6%)

  Fly     2 AAQTILFDFTLDKDKTADEEARLQVAKILRNELEQLFPQLELAYSMES-PENGYFAVLHENKDTV 65
            ||:....||.|  ...||.|.      ||:. |:.:|.:..:|.|:.: .::||.|.......:.
Human     3 AARHSTLDFML--GAKADGET------ILKG-LQSIFQEQGMAESVHTWQDHGYLATYTNKNGSF 58

  Fly    66 ITCRIFQHGLLTLNVEYFLPD--GKEPSISFDTM------RTMELILRQKFDSDRSKYLPPIKRG 122
            ...||:.|||:.|:::.:..|  |||   ..|::      |..||   .:..:.|.|.||||.||
Human    59 ANLRIYPHGLVLLDLQSYDGDAQGKE---EIDSILNKVEERMKEL---SQDSTGRVKRLPPIVRG 117

  Fly   123 GYIDIYMTSSDERIIEYDIDKVVFEARSPFQKIQIMHSKTLGNMLLLDELQNIAESDLIYTETLM 187
            |.||.|..::|.|::|||||:||::..||:|.|:|:|||..||:|:|....|:|||||.||..:|
Human   118 GAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIM 182

  Fly   188 CRGVENYEGKEICILGGGDGALLYELLKENPKHVVMLEIDELVMQTCNKYLNVICGDVLEKRKGD 252
            ..|.|:|.||::.|||||||.:|.|::|..||.|.|:|||::|:..|.||:...|||||:..|||
Human   183 GSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGD 247

  Fly   253 QYEIIVGDCVEYLKKFIAEGRKFDYVFGDLTDIPITDAPEGE-TWDFIRTIFEHSFKVLKPDGKY 316
            .|::::.||:..||::..|||:||||..|||.:||:.:||.: ||:|:|.|.:.|.||||.||||
Human   248 CYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKY 312

  Fly   317 LTHGNGSTCKVQLRLFEEQLNLLRPKVKFTTTKAFVPSFMEEWLFYQV 364
            .|.||.......|.|:||||..|...|:|:.....|||::|.|:||.|
Human   313 FTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sms	NP_001287045.1	Spermine_synt_N	<137..170	CDD:407397	18/32 (56%)
		AdoMet_MTases	180..362	CDD:473071	88/182 (48%)
SMS	NP_004586.2	SpmSyn_N	21..117	CDD:465581	29/108 (27%)
		Spermine_synt_N	123..172	CDD:407397	23/48 (48%)
		Spermine_synth	175..365	CDD:396237	91/186 (49%)