DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sms and Sms

DIOPT Version :9

Sequence 1:	NP_001287045.1	Gene:	Sms / 39403	FlyBaseID:	FBgn0036272	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001029071.1	Gene:	Sms / 363469	RGDID:	1564826	Length:	366	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	161/370 - (43%)
Similarity:	230/370 - (62%)	Gaps:	19/370 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAQTILFDFTLDKDKTADEEARLQVAKILRNELEQLFPQLELAYSMES-PENGYFAVLHENKDTV 65
            ||:....||||  ...||.||      ||:. |:.:|.:..:|.|:.: .::||.|.......:.
  Rat     3 AARHSTLDFTL--GAKADGEA------ILKG-LQSIFQEQGMAESVHTWQDHGYLATYTNKNGSF 58

  Fly    66 ITCRIFQHGLLTLNVEYFLPD--GKEPSISFDTM--RTMELILRQKFDS-DRSKYLPPIKRGGYI 125
            ...||:.|||:.|:::.:..|  ||:.:   |.:  :..|.:.....|| .|.|.||||.|||.|
  Rat    59 ANLRIYPHGLVLLDLQSYDSDVQGKQET---DCLLNKIEEKMKELSQDSTGRVKRLPPIVRGGAI 120

  Fly   126 DIYMTSSDERIIEYDIDKVVFEARSPFQKIQIMHSKTLGNMLLLDELQNIAESDLIYTETLMCRG 190
            |.|..::|.|::|||||:||::..||:|.|:|:|||..||:|:|....|:|||||.||..:|..|
  Rat   121 DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGNG 185

  Fly   191 VENYEGKEICILGGGDGALLYELLKENPKHVVMLEIDELVMQTCNKYLNVICGDVLEKRKGDQYE 255
            .|:|.||::.|||||||.:|.|::|..||.|.|:|||::|:..|.||:...|||||:..|||.|:
  Rat   186 KEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRRTCGDVLDNLKGDCYQ 250

  Fly   256 IIVGDCVEYLKKFIAEGRKFDYVFGDLTDIPITDAPEGE-TWDFIRTIFEHSFKVLKPDGKYLTH 319
            :::.||:..||::..|||:||||..|||.:||:.:||.: ||:|:|.|.:.|.||||.||||.|.
  Rat   251 VLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQ 315

  Fly   320 GNGSTCKVQLRLFEEQLNLLRPKVKFTTTKAFVPSFMEEWLFYQV 364
            ||.......|.|:||||..|...|:|:.....|||::|.|:||.|
  Rat   316 GNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sms	NP_001287045.1	AdoMet_MTases	137..362	CDD:302624	112/225 (50%)
Sms	NP_001029071.1	Spermine_synth	120..366	CDD:279850	124/247 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353985
Domainoid	1	1.000	189	1.000	Domainoid score	I3215
eggNOG	1	0.900	-	-		E1_COG0421
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88709
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2791
OMA	1	1.010	-	-		QHG52515
OrthoDB	1	1.010	-	-		D1243182at2759
OrthoFinder	1	1.000	-	-		FOG0007845
OrthoInspector	1	1.000	-	-		oto98328
orthoMCL	1	0.900	-	-		OOG6_108489
Panther	1	1.100	-	-	LDO	PTHR46315
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5802
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770