DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and AKR2

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	82/421 - (19%)
Similarity:	141/421 - (33%)	Gaps:	141/421 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RNKFYCDGLLMSAPHTGVFYLT-CILI-TGTSALFFAFDCPF-LADSINPAIPIVGAVLYFFTMS 89
            |...|...|..:...:|:|..| |.|| ..|..|:     |: ::|.....:..:  |..|.|:.
Yeast   350 RKNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLY-----PYSVSDYTMKNVQFL--VTSFLTVV 407

  Fly    90 SLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKI 154
            ..||...:|||.:  .::|....|::.|                 |:::..|:..:..:|.....
Yeast   408 LFLRLVRSDPGCL--KTDDSLTSIQETI-----------------KQLIDLGKFDRENFCVETLE 453

  Fly   155 FRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAF-LAVFIFSCSVTHLVLLM 218
            .:|.|:.:.......|.|:||:|||:.|.||.:|::.|..|.|::.: :.:|::.|     :...
Yeast   454 RKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYHMFLFMWLC-----LAYF 513

  Fly   219 KKEHEVFNVIKA------------------APFT-VIVVFICFFSIW------------------ 246
            ||.:.::..::.                  .|.| .:.::|....||
Yeast   514 KKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVNFIWLGAMLIVQFFQILKGITT 578

  Fly   247 -------------SVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQ-----------NPYSR 287
                         ..|.|..|...:.||:....||   |.....||...           .|.:|
Yeast   579 PELFILIKEEHKAKFINLIPFENSIYTSESKGVED---SDMIPEGPSATTITHTISIDGLEPRNR 640

  Fly   288 GNICLNCCHILCGPMTPSLIDRRGIATDEFI---------QQMQHQSSPRHALSDVLSASHMVT- 342
            ....|:.|..:.|      |::..:...|.:         ...||.||   .|...|..:|..|
Yeast   641 RRAILSACFSMMG------INQWLVTIKEIVGITHILHGQVPQQHHSS---LLRSFLVTNHWKTN 696

  Fly   343 -----------------------TSQPMMGG 350
                                   ||:.|:||
Yeast   697 LTDFWLNSDVTAPLWQRFFYSSDTSKAMLGG 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	33/174 (19%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738
		ANK repeat	54..81	CDD:293786
		ANK repeat	83..115	CDD:293786
		ANK repeat	117..148	CDD:293786
		ANK repeat	189..220	CDD:293786
		Ank_4	190..243	CDD:372654
		ANK repeat	222..247	CDD:293786
		COG5273	340..711	CDD:227598	77/403 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810