Protein Alignment app and ZDHHC16

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_115703.2
• Gene: ZDHHC16 / 84287
• HGNCID: 20714
• Length: 377
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 77/346 - (22%)
• Similarity: 130/346 - (37%)
• Gaps: 124/346 - (35%)

  Fly    45 VFYLTCILITGTSALFFAFDCPFLADSINPAIPIVGAVL--------YFFTMSSLLRTTF----- 96
            ||.:..|::|| |.:..|:.|         .:|::....        :|::..:|:...|
Human    82 VFVVLVIVLTG-SIVAIAYLC---------VLPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQA 136

  Fly    97 --TDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPR 159
              |.||..|:..||.|                                ||.:  |..|...:|.|
Human   137 ITTPPGYPPQGRNDIA--------------------------------TVSI--CKKCIYPKPAR 167

  Fly   160 ASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCS-------------V 211
            ..|||:|:.||.:.||||||:.||||..|:|:|:.|...:....|:   ||             :
Human   168 THHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVY---CSYGSWDLFREAYAAI 229

  Fly   212 THLVLLMKKE-----HEVFNVIKAAPFT----------VIVVFICFFSIWSVIGLAGFHTYLTTS 261
            ..:..|.|.:     ::.::......|:          |.:.|:|.....::..|..:|..|.:.
Human   230 EKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHAVLISR 294

  Fly   262 DQTT-----NEDLKGSFSSKGGPRT-QNPYSRGNICLNCCHILCGPMTPSLIDRRGIATDEFIQQ 320
            .:|:     |:..:....:||  |. :|||:.|  ||:...:..|      :|
Human   295 GETSIERHINKKERRRLQAKG--RVFRNPYNYG--CLDNWKVFLG------VD------------ 337

  Fly   321 MQHQSSPRHALSDV-LSASHM 340
                 :.||.|:.| |.:||:
Human   338 -----TGRHWLTRVLLPSSHL 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	38/156 (24%)
ZDHHC16	NP_115703.2	DHHC	156..305	CDD:396215	37/153 (24%)