DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	339	Identity:	196/339 - (57%)
Similarity:	247/339 - (72%)	Gaps:	20/339 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QRVTRKWELFAGRNKFYCDGLLMSAPHTGVFYLTCILITGTSALFFAFDCPFLADSINPAIPIVG 80
            :|..||||:|.|||:|||.|.||.|.|.|||.||.:||..|:.|||.||||:||..:..||||:.
Human    64 RRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLILTTTGLFFVFDCPYLARKLTLAIPIIA 128

  Fly    81 AVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVK 145
            |:|:||.||.||:|:|||||::|||:..|||.:||||:   :..|.||||||||:|||:.||.||
Human   129 AILFFFVMSCLLQTSFTDPGILPRATVCEAAALEKQID---NTGSSTYRPPPRTREVLINGQMVK 190

  Fly   146 LKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCS 210
            ||||||||:|||||.||||:|||||:||||||||||||||:|||||||.|::||:||..|||:|.
Human   191 LKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACV 255

  Fly   211 VTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSS 275
            ||||.|..:..: ..:.:|..|.:|:.:.||||||||::||:||||||..|:.|||||:|||:||
Human   256 VTHLTLRAQGSN-FLSTLKETPASVLELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSS 319

  Fly   276 K-GGPRTQNPYSRGNICLNCCHILCGPMTPSLIDRRGIATDEFIQQMQHQSSPRHALSDVLSASH 339
            | ||..:.||||..:|..|||.:||||:.||||||||     |:|......||       :.:..
Human   320 KRGGEASVNPYSHKSIITNCCAVLCGPLPPSLIDRRG-----FVQSDTVLPSP-------IRSDE 372

  Fly   340 MVTTSQP---MMGG 350
            ....::|   |:||
Human   373 PACRAKPDASMVGG 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	82/123 (67%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		1/2 (50%)
		zf-DHHC	191..314	CDD:279823	82/123 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388		6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2911
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	1	1.000	-	-		otm42161
orthoMCL	1	0.900	-	-		OOG6_100625
Panther	1	1.100	-	-	O	PTHR22883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	1	1.000	-	-		X394
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810